CTNNB1

Summary

Gene Symbol: CTNNB1
Description: catenin beta 1
Alias: CHBCAT, catenin beta-1, beta catenin, catenin (cadherin-associated protein), beta 1, 88kDa
Species: chicken

Top Publications

  1. ncbi Isolation and characterization of chicken beta-catenin
    J Lu
    Department of Pathology, School of Medicine, University of Southern California, Los Angeles, USA
    Gene 196:201-7. 1997
  2. doi Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole
    Antonio Herrera
    Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Rossello 161, Barcelona 08036, Spain
    Nat Commun 5:4168. 2014
  3. doi Hormonal regulation of beta-catenin during development of the avian oviduct and its expression in epithelial cell-derived ovarian carcinogenesis
    Seung Min Bae
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, 1 Gwanak ro, Gwanak Gu, Seoul 151 742, Republic of Korea
    Mol Cell Endocrinol 382:46-54. 2014
  4. pmc Sex-specific expression of CTNNB1 in the gonadal morphogenesis of the chicken
    Seung Min Bae
    Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136 713, Republic of Korea
    Reprod Biol Endocrinol 11:89. 2013
  5. pmc Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation
    Ang Li
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 110:E1452-61. 2013
  6. pmc Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression
    Shumin Bian
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e28264. 2011
  7. ncbi Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription
    Jinseol Rhee
    Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242 1324, USA
    Nat Cell Biol 9:883-92. 2007
  8. doi The promoting effect of retinoic acid on proliferation of chicken primordial germ cells by increased expression of cadherin and catenins
    Minli Yu
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of the Ministry of Agriculture, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No 268 Kaixuan Road, Hangzhou, People s Republic of China
    Amino Acids 40:933-41. 2011
  9. pmc Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin
    Bau Lin Huang
    Department of Oral Biology, UCLA School of Dentistry, Los Angeles, California 90095, USA
    J Biol Chem 285:27702-12. 2010
  10. pmc Regulation of cadherin expression in the chicken neural crest by the Wnt/β-catenin signaling pathway
    Abha J Chalpe
    Department of Biology, University of South Dakota, Vermillion, SD, USA
    Cell Adh Migr 4:431-8. 2010

Scientific Experts

  • Gwonhwa Song
  • Anthony D Person
  • Seung Min Bae
  • Antonio Herrera
  • Jin Young Lee
  • Whasun Lim
  • Fuller W Bazer
  • Wooyoung Jeong
  • JinYoung Kim
  • Ang Li
  • Minli Yu
  • Shumin Bian
  • Bau Lin Huang
  • Patricia L Martinez-Morales
  • Ian Brauner
  • Abha J Chalpe
  • Dongkyun Kim
  • Melania E Mercado-Pimentel
  • Jinseol Rhee
  • Young Ho Lee
  • Catherine K Yang
  • Seo Hee Cho
  • Michael R Stallcup
  • Yoshihiro Tamamura
  • Maike Schmidt
  • Annemieke A de Melker
  • Wei V Zhang
  • Fumi Kubo
  • Elisa Marti
  • Jae Yong Han
  • Sebastian Pons
  • Murielle Saade
  • Anghara Menendez
  • Cheng Ming Chuong
  • Ting Xin Jiang
  • Ping Wu
  • Qing Nie
  • Randall Widelitz
  • Meng Chen
  • Y Kawakami
  • Hannah Chapin
  • Dhasakumar S Navaratnam
  • Cathy Le Moellic
  • Huiping Dong
  • Jun Ping Bai
  • Fred J Sigworth
  • Michael Caplan
  • Caiqiao Zhang
  • Kun Guan
  • Amanda J Henke
  • Alejandra C Quiroga
  • Judith M Venuti
  • Aixa V Morales
  • Alicia F Paulson
  • Sean M Brugger
  • Julio A Barbas
  • Douglas B Spicer
  • Karen M Lyons
  • Maneeshi Prasad
  • Catherine E Krull
  • Shin Sung Kang
  • Eun Jung Jin
  • Jungsoo Kim
  • Jack Lilien
  • Tim Buchan
  • Janne Balsamo
  • Antony D Hubbard
  • Lawrence Zukerberg
  • Raymond B Runyan
  • Jeong Hoon Kim
  • Hongwei Li
  • Constance L Cepko
  • Motomi Enomoto-Iwamoto
  • Tomohiro Otani
  • Naoko Kanatani
  • Masahiro Iwamoto
  • Frank Costantini
  • Jirota Kitagaki
  • Yoshihiko Yamada
  • Satoshi Wakisaka
  • Eiki Koyama
  • Toshihisa Komori
  • Maurizio Pacifici
  • Margaret Patterson
  • Nathalie Desban
  • Jean Loup Duband
  • J Lu
  • Andrea Munsterberg
  • N Susan Stott
  • Elizabeth Farrell

Detail Information

Publications24

  1. ncbi Isolation and characterization of chicken beta-catenin
    J Lu
    Department of Pathology, School of Medicine, University of Southern California, Los Angeles, USA
    Gene 196:201-7. 1997
    ..In-situ hybridization and immunostaining showed that in the developing limb, it is specifically expressed in the apical ectodermal ridge, suggesting a role in epithelial-mesenchymal interactions...
  2. doi Sustained Wnt/β-catenin signalling causes neuroepithelial aberrations through the accumulation of aPKC at the apical pole
    Antonio Herrera
    Instituto de Investigaciones Biomédicas de Barcelona, CSIC IDIBAPS, Rossello 161, Barcelona 08036, Spain
    Nat Commun 5:4168. 2014
    ..Therefore, we conclude that β-catenin controls the cell fate and polarity of the neuroblasts through the expression and localization of aPKC. ..
  3. doi Hormonal regulation of beta-catenin during development of the avian oviduct and its expression in epithelial cell-derived ovarian carcinogenesis
    Seung Min Bae
    WCU Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, 1 Gwanak ro, Gwanak Gu, Seoul 151 742, Republic of Korea
    Mol Cell Endocrinol 382:46-54. 2014
    Beta-catenin (CTNNB1) is a dual function molecule that acts as a key component of the cadherin complex and WNT signaling pathway. It has a crucial role in embryogenesis, tumorigenesis, angiogenesis and progression of metastasis...
  4. pmc Sex-specific expression of CTNNB1 in the gonadal morphogenesis of the chicken
    Seung Min Bae
    Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136 713, Republic of Korea
    Reprod Biol Endocrinol 11:89. 2013
    Beta-catenin (CTNNB1), as a key transcriptional regulator in the WNT signal transduction cascade, plays a pivotal role in multiple biological functions such as embryonic development and homeostasis in adults...
  5. pmc Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation
    Ang Li
    Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 110:E1452-61. 2013
    ....
  6. pmc Interactions between β-catenin and the HSlo potassium channel regulates HSlo surface expression
    Shumin Bian
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e28264. 2011
    ..Prior work has shown that Slo, through its S10 region, interacts with β-catenin, a key component of the cytoskeleton framework and the Wnt signaling pathway. However, the physiological significance of this interaction was not clear...
  7. ncbi Cables links Robo-bound Abl kinase to N-cadherin-bound beta-catenin to mediate Slit-induced modulation of adhesion and transcription
    Jinseol Rhee
    Department of Biological Sciences, The University of Iowa, Iowa City, Iowa 52242 1324, USA
    Nat Cell Biol 9:883-92. 2007
    ..Thus, Slit-induced formation of the Robo-N-cadherin complex results in a rapid loss of cadherin-mediated adhesion and has more lasting effects on gene transcription...
  8. doi The promoting effect of retinoic acid on proliferation of chicken primordial germ cells by increased expression of cadherin and catenins
    Minli Yu
    Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of the Ministry of Agriculture, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, No 268 Kaixuan Road, Hangzhou, People s Republic of China
    Amino Acids 40:933-41. 2011
    ..These results indicate that RA, as a bioactive metabolite of vitamin A, may promote PGC proliferation and increase intercellular aggregation of PGCs via E-cadherin and α/β-catenins expression through the PKC signaling pathway...
  9. pmc Stage-specific control of connective tissue growth factor (CTGF/CCN2) expression in chondrocytes by Sox9 and beta-catenin
    Bau Lin Huang
    Department of Oral Biology, UCLA School of Dentistry, Los Angeles, California 90095, USA
    J Biol Chem 285:27702-12. 2010
    ..Hence, we propose that differential occupancy of the TCF x LEF x Sox9 site by Sox9 versus beta-catenin restricts high levels of Ccn2 expression to hypertrophic chondrocytes...
  10. pmc Regulation of cadherin expression in the chicken neural crest by the Wnt/β-catenin signaling pathway
    Abha J Chalpe
    Department of Biology, University of South Dakota, Vermillion, SD, USA
    Cell Adh Migr 4:431-8. 2010
    ....
  11. pmc SOX5 controls cell cycle progression in neural progenitors by interfering with the WNT-beta-catenin pathway
    Patricia L Martinez-Morales
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Doctor Arce 37, 28002 Madrid, Spain
    EMBO Rep 11:466-72. 2010
    ..We propose that SOX5 regulates the timing of cell cycle exit by opposing WNT-beta-catenin activity on cell cycle progression...
  12. doi Identification of responsive cells in the developing somite supports a role for beta-catenin-dependent Wnt signaling in maintaining the DML myogenic progenitor pool
    Ian Brauner
    Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Dev Dyn 239:222-36. 2010
    ....
  13. doi Transforming growth factor-beta3-induced Smad signaling regulates actin reorganization during chondrogenesis of chick leg bud mesenchymal cells
    Dongkyun Kim
    Department of Biological Sciences, Wonkwang University, Iksan, Chunbuk, South Korea
    J Cell Biochem 107:622-9. 2009
    ..Biochem. (c) 2009 Wiley-Liss, Inc.This article was published online on 28 May 2009. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 8 June 2009...
  14. pmc Endoglin and Alk5 regulate epithelial-mesenchymal transformation during cardiac valve formation
    Melania E Mercado-Pimentel
    Department of Cell Biology and Anatomy, University of Arizona, 1501 N Campbell Ave, P O Box 245044, Tucson, AZ 85724 5044, USA
    Dev Biol 304:420-32. 2007
    ....
  15. pmc Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription
    Young Ho Lee
    Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Avenue, MCA 51A, Los Angeles, CA 90089, USA
    Nucleic Acids Res 34:5052-9. 2006
    ....
  16. ncbi Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye
    Seo Hee Cho
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 133:3167-77. 2006
    ..Because wingless (wg) plays a similar role in the induction of peripheral eye tissues of Drosophila, these findings indicate a possible conservation of the process that patterns the photoreceptive and support structures of the eye...
  17. pmc Differential use of functional domains by coiled-coil coactivator in its synergistic coactivator function with beta-catenin or GRIP1
    Catherine K Yang
    Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    J Biol Chem 281:3389-97. 2006
    ..Thus, CoCoA uses different combinations of functional domains to serve as a physiologically relevant component of the Wnt/beta-catenin signaling pathway and the androgen signaling pathway...
  18. ncbi BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin
    Wei V Zhang
    Department of Surgery, Faculty of Medicine and Health Science, The University of Auckland, Auckland, New Zealand
    Cell Commun Adhes 11:89-102. 2004
    ..b>Beta catenin mediated nuclear signaling has been implicated in BMP-2-modulated chondrogenic differentiation in the ..
  19. ncbi Cellular localization and signaling activity of beta-catenin in migrating neural crest cells
    Annemieke A de Melker
    Laboratoire de Biologie du Developpement, CNRS et Université Pierre et Marie Curie, Paris, France
    Dev Dyn 230:708-26. 2004
    ....
  20. ncbi Dynamic expression of Lef/Tcf family members and beta-catenin during chick gastrulation, neurulation, and early limb development
    Maike Schmidt
    University of Dundee, School of Life Sciences Biocentre, Dundee, Scotland, United Kingdom
    Dev Dyn 229:703-7. 2004
    ....
  21. ncbi Wnt2b controls retinal cell differentiation at the ciliary marginal zone
    Fumi Kubo
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa Oiwake cho, Kyoto 606 8502, Japan
    Development 130:587-98. 2003
    ..These results suggest that Wnt2b functions to maintain undifferentiated progenitor cells in the ciliary marginal zone, and thus serves as a putative stem cell factor in the retina...
  22. ncbi WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo
    Y Kawakami
    The Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 104:891-900. 2001
    ..Thus, three WNT signals mediated by beta-catenin control both limb initiation and AER induction in the vertebrate embryo...
  23. ncbi Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification
    Yoshihiro Tamamura
    Department of Orthopaedic Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 280:19185-95. 2005
    ....
  24. ncbi Frzb modulates Wnt-9a-mediated beta-catenin signaling during avian atrioventricular cardiac cushion development
    Anthony D Person
    Department of Cell Biology and Anatomy, University Medical Center, University of Arizona School of Medicine, 1501 N Campbell Avenue, PO Box 245044, Tucson, AZ 85724, USA
    Dev Biol 278:35-48. 2005
    ..Together, these data argue that Wnt-9a and Frzb regulate mesenchymal cell proliferation leading to proper AV canal cushion outgrowth and remodeling in the developing avian heart...