Gene Symbol: CTCF
Description: CCCTC-binding factor
Alias: transcriptional repressor CTCF, 11-zinc finger protein, CCCTC-binding factor (zinc finger protein), CTCFL paralog
Klenova E, Nicolas R, Paterson H, Carne A, Heath C, Goodwin G, et al
. CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms. Mol Cell Biol. 1993;13:7612-24 pubmed
A novel sequence-specific DNA-binding protein, CTCF, which interacts with the chicken c-myc gene promoter, has been identified and partially characterized (V. V. Lobanenkov, R. H. Nicolas, V. V. Adler, H. Paterson, E. M. Klenova, A. V...
Lutz M, Burke L, Barreto G, Goeman F, Greb H, Arnold R, et al
. Transcriptional repression by the insulator protein CTCF involves histone deacetylases. Nucleic Acids Res. 2000;28:1707-13 pubmed
The highly conserved zinc-finger protein, CTCF, is a candidate tumor suppressor protein that binds to highly divergent DNA sequences...
Klenova E, Scott A, Roberts J, Shamsuddin S, Lovejoy E, Bergmann S, et al
. YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders. J Neurosci. 2004;24:5966-73 pubmed
..Interestingly, the transcription factor CCTC-binding factor (CTCF), previously shown to interact with YB-1, interferes with the ability of the VNTR to support YB-1-directed reporter ..
Klochkov D, Rincón Arano H, Ioudinkova E, Valadez Graham V, Gavrilov A, Recillas Targa F, et al
. A CTCF-dependent silencer located in the differentially methylated area may regulate expression of a housekeeping gene overlapping a tissue-specific gene domain. Mol Cell Biol. 2006;26:1589-97 pubmed
..kb upstream to the chicken alpha-globin gene cluster contains a binding site for the multifunctional protein factor CTCF and possesses silencer activity which depends on CTCF binding, as demonstrated by site-directed mutagenesis of the ..
Canto Soler M, Huang H, Romero M, Adler R. Transcription factors CTCF and Pax6 are segregated to different cell types during retinal cell differentiation. Dev Dyn. 2008;237:758-67 pubmed publisher
We have hypothesized that the transcription factor CTCF may influence retinal cell differentiation by controlling Pax6 expression, because (1) CTCF has been shown to repress Pax6 expression in some tissues, and (2) Pax6 blocks the ..
Valdes Quezada C, Arriaga Canon C, Fonseca Guzmán Y, Guerrero G, Recillas Targa F. CTCF demarcates chicken embryonic ?-globin gene autonomous silencing and contributes to adult stage-specific gene expression. Epigenetics. 2013;8:827-38 pubmed publisher
..The multifunctional CCCTCC-binding factor (CTCF), which is located upstream of the ?(D) gene promoter, delimits this sub-domain and creates a transition between ..
Yusufzai T, Felsenfeld G. The 5'-HS4 chicken beta-globin insulator is a CTCF-dependent nuclear matrix-associated element. Proc Natl Acad Sci U S A. 2004;101:8620-4 pubmed
The protein CTCF plays an essential role in the action of a widely distributed class of vertebrate enhancer-blocking insulators, of which the first example was found in a DNA sequence element, HS4, at the 5' end of the chicken beta-globin ..