CHRNA9

Summary

Gene Symbol: CHRNA9
Description: cholinergic receptor nicotinic alpha 9 subunit
Alias: neuronal acetylcholine receptor subunit alpha-9, NACHR alpha-9, cholinergic receptor, nicotinic, alpha 9 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 9, nicotinic acetylcholine receptor subunit alpha-9
Species: chicken
Products:     CHRNA9

Top Publications

  1. Hiel H, Luebke A, Fuchs P. Cloning and expression of the alpha9 nicotinic acetylcholine receptor subunit in cochlear hair cells of the chick. Brain Res. 2000;858:215-25 pubmed
    ..These findings suggest that alpha9 contributes to the ACh receptor of avian hair cells and supports the generality of this hypothesis among all vertebrates. ..
  2. Lipovsek M, Im G, Franchini L, Pisciottano F, Katz E, Fuchs P, et al. Phylogenetic differences in calcium permeability of the auditory hair cell cholinergic nicotinic receptor. Proc Natl Acad Sci U S A. 2012;109:4308-13 pubmed publisher
    ..In addition, they suggest that high Ca(2+) permeability of the ?9?10 cholinergic nicotinic receptor might have evolved together with other features that have given the mammalian ear an expanded high-frequency sensitivity...
  3. Boffi J, Marcovich I, Gill Thind J, Corradi J, Collins T, Lipovsek M, et al. Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function. Mol Pharmacol. 2017;91:250-262 pubmed publisher
    ..We conclude that this asymmetry, which is supported by molecular docking studies, results from adaptive amino acid changes acquired only during the evolution of mammalian α10 subunits. ..