Gene Symbol: CHRNA3
Description: cholinergic receptor nicotinic alpha 3 subunit
Alias: neuronal acetylcholine receptor subunit alpha-3, cholinergic receptor, nicotinic, alpha 3 (neuronal), cholinergic receptor, nicotinic, alpha polypeptide 3
Couturier S, Erkman L, Valera S, Rungger D, Bertrand S, Boulter J, et al
. Alpha 5, alpha 3, and non-alpha 3. Three clustered avian genes encoding neuronal nicotinic acetylcholine receptor-related subunits. J Biol Chem. 1990;265:17560-7 pubmed
..alpha 5, however, did not direct the assembly of functional nAChRs when injected alone or in combination with n alpha 1 or n alpha 3. ..
Balestra B, Vailati S, Moretti M, Hanke W, Clementi F, Gotti C. Chick optic lobe contains a developmentally regulated alpha2alpha5beta2 nicotinic receptor subtype. Mol Pharmacol. 2000;58:300-11 pubmed
..These channels are activated by nicotinic agonists in a dose-dependent manner and are blocked by the nicotinic antagonist d-tubocurarine. ..
Rosenberg M, Yang F, Giovanni M, Mohn J, Temburni M, Jacob M. Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex. Mol Cell Neurosci. 2008;38:138-52 pubmed publisher
..This work identifies macrophin, IQGAP1 and 14-3-3 as novel nicotinic synapse components and defines a new role for APC as an in vivo coordinator of nicotinic postsynaptic assembly in vertebrate neurons. ..
Fernandes C, Berg D, Gomez Varela D. Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type. J Neurosci. 2010;30:8841-51 pubmed publisher
..The outcome is a system that could tailor nicotinic signaling capabilities to specific needs of individual locations. ..
Nef P, Oneyser C, Alliod C, Couturier S, Ballivet M. Genes expressed in the brain define three distinct neuronal nicotinic acetylcholine receptors. EMBO J. 1988;7:595-601 pubmed
..The same set of neuronal genes probably exists in all vertebrates since their counterparts have also been identified in the rat genome. ..
Conroy W, Berg D. Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit compositions. J Biol Chem. 1995;270:4424-31 pubmed
..The identification of three acetylcholine receptor subtypes distinguished by subunit composition on the same neurons provokes questions about their individual physiological roles. ..