Gene Symbol: CEBPB
Description: CCAAT/enhancer binding protein beta
Alias: NF-M, CCAAT/enhancer-binding protein beta, CCAAT box/enhancer binding protein beta, CCAAT/enhancer binding protein (C/EBP), beta, CCR protein, c/EBP beta, transcription factor NF-M
Burk O, Mink S, Ringwald M, Klempnauer K. Synergistic activation of the chicken mim-1 gene by v-myb and C/EBP transcription factors. EMBO J. 1993;12:2027-38 pubmed
..Our results suggest a role for C/EBP beta, and possibly for other C/EBP transcription factors, in v-myb function and in myeloid-specific gene activation...
Kim S, Mao P, Gagliardi M, Bedard P. C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. Mol Cell Biol. 1999;19:5718-31 pubmed
..Therefore, we have identified C/EBPbeta as a key activator of a growth arrest-specific gene in CEF and implicated an essential fatty acid, linoleic acid, in regulation of the QRU and the p20K lipocalin gene. ..
Steinmann S, Schulte K, Beck K, Chachra S, Bujnicki T, Klempnauer K. v-Myc inhibits C/EBPbeta activity by preventing C/EBPbeta-induced phosphorylation of the co-activator p300. Oncogene. 2009;28:2446-55 pubmed publisher
..Overall, our findings that the modulation of the C/EBPbeta-induced phosphorylation of p300 as a new mechanism of transcriptional suppression by v-Myc. ..
Kowenz Leutz E, Pless O, Dittmar G, Knoblich M, Leutz A. Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code. EMBO J. 2010;29:1105-15 pubmed publisher
..Thus, phosphorylation of the transcription factor C/EBPbeta couples ras signalling to arginine methylation and regulates the interaction of C/EBPbeta with epigenetic gene regulatory protein complexes during cell differentiation. ..
Fu R, Liu R, Zhao G, Zheng M, Chen J, Wen J. Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens. Gene. 2014;537:120-5 pubmed publisher
..Taken together, all five transcription factors studied play roles in lipid metabolism in chickens with C/EBP? and PPAR? being important effectors. ..
Katz S, Kowenz Leutz E, Muller C, Meese K, Ness S, Leutz A. The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J. 1993;12:1321-32 pubmed
..Our data indicate that NF-M plays a key role in myelomonocytic differentiation, in signal transduction during macrophage activation and in the development of myelogenous leukemia. ..
Kintscher J, Yamkamon V, Braas D, Klempnauer K. Identification of a Myb-responsive enhancer of the chicken C/EBPbeta gene. Oncogene. 2004;23:5807-14 pubmed
..Apart from the identification of a novel Myb-dependent enhancer, our work demonstrates the potential of chromatin structure analysis for the identification of Myb target sites. ..
Goethe R, Basler T, Phi van L. Regulation of C/EBPbeta mRNA expression and C/EBPbeta promoter activity by protein kinases A and C in a myelomonocytic cell line (HD11). Inflamm Res. 2007;56:274-81 pubmed
Plachetka A, Chayka O, Wilczek C, Melnik S, Bonifer C, Klempnauer K. C/EBPbeta induces chromatin opening at a cell-type-specific enhancer. Mol Cell Biol. 2008;28:2102-12 pubmed publisher
..Our work identifies a novel function for C/EBPbeta in the initial steps of a localized chromatin opening at a specific, physiologically relevant target region. ..