Gene Symbol: CEBPA
Description: CCAAT/enhancer binding protein alpha
Alias: cC/EBP, CCAAT/enhancer-binding protein alpha, CCAAT/enhancer binding protein (C/EBP), alpha
Calkhoven C, Ab G, Wijnholds J. c/CEPB, a chicken transcription factor of the leucine-zipper C/EBP family [corrected]. Nucleic Acids Res. 1992;20:4093 pubmed
Calkhoven C, Gringhuis S, Ab G. The chicken CCAAT/enhancer binding protein alpha gene. Cloning, characterisation and tissue distribution. Gene. 1997;196:219-29 pubmed
..Recombinant cC/EBP alpha binds to its cognate C/EBP binding site as a homodimer or as a heterodimer with the related cC/EBP beta/NF-M. ..
Liu S, Wang Y, Wang L, Wang N, Li Y, Li H. Transdifferentiation of fibroblasts into adipocyte-like cells by chicken adipogenic transcription factors. Comp Biochem Physiol A Mol Integr Physiol. 2010;156:502-8 pubmed publisher
..This suggests that C/EBPalpha, PPARgamma and SREBP-1 play a crucial role in chicken adipogenesis. ..
Fu R, Liu R, Zhao G, Zheng M, Chen J, Wen J. Expression profiles of key transcription factors involved in lipid metabolism in Beijing-You chickens. Gene. 2014;537:120-5 pubmed publisher
..Taken together, all five transcription factors studied play roles in lipid metabolism in chickens with C/EBP? and PPAR? being important effectors. ..
Yang Q, Tang S, Dong L, Chen Q, Liu X, Jiang J, et al
. Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer-binding protein ? and hepatocyte nuclear factor 4?. FEBS J. 2014;281:1379-92 pubmed publisher
..In conclusion, the data indicate that the constitutive hepatic expression of CYP2D49 is governed by both C/EBP? and HNF4?. Further studies will be required to fully characterize the molecular mechanisms that modulate CYP2D49 expression. ..
Yu X, Liu R, Zhao G, Zheng M, Chen J, Wen J. Folate supplementation modifies CCAAT/enhancer-binding protein ? methylation to mediate differentiation of preadipocytes in chickens. Poult Sci. 2014;93:2596-603 pubmed publisher
Gao Y, Sun Y, Duan K, Shi H, Wang S, Li H, et al
. CpG site DNA methylation of the CCAAT/enhancer-binding protein, alpha promoter in chicken lines divergently selected for fatness. Anim Genet. 2015;46:410-7 pubmed publisher
CCAAT/enhancer-binding protein (C/EBP), alpha (CEBPA) is a master regulator of adipogenesis and, together with peroxisome proliferator-activated receptor gamma (PPARG), plays a critical role in adipocyte differentiation...