Gene Symbol: CDH7
Description: cadherin 7
Alias: cadherin-7, cadherin-7, cadherin 7, type 2
Species: chicken
Products:     CDH7

Top Publications

  1. Chalpe A, Prasad M, Henke A, Paulson A. Regulation of cadherin expression in the chicken neural crest by the Wnt/?-catenin signaling pathway. Cell Adh Migr. 2010;4:431-8 pubmed
  2. Nakagawa S, Takeichi M. Neural crest cell-cell adhesion controlled by sequential and subpopulation-specific expression of novel cadherins. Development. 1995;121:1321-32 pubmed
    ..The cadherin-mediated specific interaction between crest cells likely plays a role in intercellular signaling between homotypic cells as well as in sorting of heterotypic cells. ..
  3. Nakagawa S, Takeichi M. Neural crest emigration from the neural tube depends on regulated cadherin expression. Development. 1998;125:2963-71 pubmed
    ..These findings suggest that the regulation of cadherin expression or its activity at the neural crest-forming area plays a critical role in neural crest emigration from the neural tube. ..
  4. Heyers D, Luksch H, Redies C. Selective synaptic cadherin expression by traced neurons of the chicken visual system. Neuroscience. 2004;127:901-12 pubmed
    ..Our findings support the idea that a cadherin-based adhesive mechanism can mediate synaptic specificity. ..
  5. Chu Y, Eder O, Thomas W, Simcha I, Pincet F, Ben Ze ev A, et al. Prototypical type I E-cadherin and type II cadherin-7 mediate very distinct adhesiveness through their extracellular domains. J Biol Chem. 2006;281:2901-10 pubmed
  6. Matsunaga E, Okanoya K. Expression analysis of cadherins in the songbird brain: relationship to vocal system development. J Comp Neurol. 2008;508:329-42 pubmed publisher
    ..These patterns of song nuclei related expression suggest the possibility that cadherins are involved in the formation and maintenance of the song nuclei or neural pathways of the song system. ..
  7. Barnes S, Price S, Wentzel C, Guthrie S. Cadherin-7 and cadherin-6B differentially regulate the growth, branching and guidance of cranial motor axons. Development. 2010;137:805-14 pubmed publisher
    ..We also demonstrate that Cad6B functions via the phosphatidylinositol 3-kinase pathway. Together, these data show that Cad7 and Cad6B differentially regulate cranial motoneuron growth, branching and axon guidance. ..
  8. Wu C, Hooper R, Han K, Taneyhill L. Migratory neural crest cell ?N-catenin impacts chick trigeminal ganglia formation. Dev Biol. 2014;392:295-307 pubmed publisher
    ..Together, these results highlight a novel function for ?N-catenin in migratory neural crest cells that form the trigeminal ganglia...
  9. Lin J, Wang C, Yang C, Fu S, Redies C. Pax3 and Pax7 interact reciprocally and regulate the expression of cadherin-7 through inducing neuron differentiation in the developing chicken spinal cord. J Comp Neurol. 2016;524:940-62 pubmed publisher
    ..Collectively, these results suggest that the transcription factors Pax3 and Pax7 play important roles in regulating morphogenesis and cell differentiation in the developing spinal cord. ..

More Information


  1. Kawano R, Matsuo N, Tanaka H, Nasu M, Yoshioka H, Shirabe K. Identification and characterization of a soluble cadherin-7 isoform produced by alternative splicing. J Biol Chem. 2002;277:47679-85 pubmed
  2. Luo J, Ju M, Redies C. Regionalized cadherin-7 expression by radial glia is regulated by Shh and Pax7 during chicken spinal cord development. Neuroscience. 2006;142:1133-43 pubmed
    ..Our data show, for the first time, that Shh can regulate the expression not only of other gene regulatory factors, but also of Cad7, a morphoregulatory molecule that plays a role in axon elongation and neural circuit formation. ..
  3. Kim D, Kang S, Jin E. Alterations in the temporal expression and function of cadherin-7 inhibit cell migration and condensation during chondrogenesis of chick limb mesenchymal cells in vitro. J Cell Physiol. 2009;221:161-70 pubmed publisher
    ..Collectively, our results suggest that cadherin-7 controls cell migration in chick limb bud mesenchymal cells, and that p38MAPK and GSK signals are responsible for regulating cadherin-7-mediated cell migration. ..
  4. Bello S, Millo H, Rajebhosale M, Price S. Catenin-dependent cadherin function drives divisional segregation of spinal motor neurons. J Neurosci. 2012;32:490-505 pubmed publisher
    ..Our results show that γ-catenin-dependent cadherin function is required for spinal motor neuron migration and divisional segregation and suggest a prolonged role for cadherin expression in all phases of motor neuron organization. ..