Genomes and Genes
Gene Symbol: c myc
Description: MYC proto-oncogene, bHLH transcription factor
Alias: c-myc, myc proto-oncogene protein, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene-like protein
Products: c myc
- Hahn M, Hayward W. Absence of missense mutations in activated c-myc genes in avian leukosis virus-induced B-cell lymphomas. Mol Cell Biol. 1988;8:2659-63 pubmed
- Shih C, Linial M, Goodenow M, Hayward W. Nucleotide sequence 5' of the chicken c-myc coding region: localization of a noncoding exon that is absent from myc transcripts in most avian leukosis virus-induced lymphomas. Proc Natl Acad Sci U S A. 1984;81:4697-701 pubmed..Sequences from the upstream noncoding exon were absent from the myc transcripts in these lymphomas; RNA transcripts from the normal c-myc allele were not expressed at detectable levels. ..
- Chesters P, Howes K, Petherbridge L, Evans S, Payne L, Venugopal K. The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively. J Gen Virol. 2002;83:2553-61 pubmed..Induction of both LL and ML by the two chimeric viruses occurred through the activation of c-myc, while the EB tumours were induced by activation of the c-erbB oncogene...
- Chi J, Teng M, Yu Z, Xu H, Su J, Zhao P, et al. Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-Î² signaling pathway. Virology. 2015;476:72-84 pubmed publisher..Our findings reveal a novel and important mechanism of how mdv1-miR-M4-5p potentially contributes to MDV-induced tumorigenesis. ..