AICDA

Summary

Gene Symbol: AICDA
Description: activation induced cytidine deaminase
Alias: AID, single-stranded DNA cytosine deaminase
Species: chicken

Top Publications

  1. Tanaka A, Shen H, Ratnam S, Kodgire P, Storb U. Attracting AID to targets of somatic hypermutation. J Exp Med. 2010;207:405-15 pubmed publisher
    ..process of somatic hypermutation (SHM) of immunoglobulin (Ig) genes requires activation-induced cytidine deaminase (AID)...
  2. Luo H, Tian M. Transcription factors PU.1 and IRF4 regulate activation induced cytidine deaminase in chicken B cells. Mol Immunol. 2010;47:1383-95 pubmed publisher
    ..Ig gene conversion is initiated by a B cell-specific enzyme, activation induced cytidine deaminase (AID)...
  3. BudzyƄska P, Kylaniemi M, Kallonen T, Soikkeli A, Nera K, Lassila O, et al. Bach2 regulates AID-mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells. Eur J Immunol. 2017;47:993-1001 pubmed publisher
    ..SHM and CSR are initiated by activation-induced cytidine deaminase (AID) which has potential to induce human B cell lymphoma...
  4. H sler J, Rada C, Neuberger M. Cytoplasmic activation-induced cytidine deaminase (AID) exists in stoichiometric complex with translation elongation factor 1? (eEF1A). Proc Natl Acad Sci U S A. 2011;108:18366-71 pubmed publisher
    Activation-induced cytidine deaminase (AID) is a B lymphocyte-specific DNA deaminase that acts on the Ig loci to trigger antibody gene diversification...
  5. Kodgire P, Mukkawar P, Ratnam S, Martin T, Storb U. Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID. J Exp Med. 2013;210:1481-92 pubmed publisher
    Somatic hypermutation (SHM) of Ig genes is initiated by the activation-induced cytidine deaminase (AID), and requires target gene transcription. We previously proposed that AID may associate with the RNA polymerase II (Pol)...
  6. Kim Y, Tian M. The recruitment of activation induced cytidine deaminase to the immunoglobulin locus by a regulatory element. Mol Immunol. 2010;47:1860-5 pubmed publisher
    Activation induced cytidine deaminase (AID) is critical for the diversification of immunoglobulin (Ig)...
  7. Chowdhury S, Kitamura K, Simadu M, Koura M, Muramatsu M. Concerted action of activation-induced cytidine deaminase and uracil-DNA glycosylase reduces covalently closed circular DNA of duck hepatitis B virus. FEBS Lett. 2013;587:3148-52 pubmed publisher
    ..Recent studies suggest that activation-induced cytidine deaminase (AID) functions in innate immunity, although its molecular mechanism of action remains unclear, particularly regarding ..
  8. Lanning D, Knight K. Diversification of the Primary Antibody Repertoire by AID-Mediated Gene Conversion. Results Probl Cell Differ. 2015;57:279-93 pubmed publisher
    Gene conversion, mediated by activation-induced cytidine deaminase (AID), has been found to contribute to generation of the primary antibody repertoire in several vertebrate species...
  9. Kawaguchi Y, Nariki H, Kawamoto N, Kanehiro Y, Miyazaki S, Suzuki M, et al. SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus. Biochem Biophys Res Commun. 2017;485:261-266 pubmed publisher
    Activation-induced cytidine deaminase (AID) is essential for diversification of the Ig variable region (IgV). AID is excluded from the nucleus, where it normally functions...