APOBEC3C

Summary

Gene Symbol: APOBEC3C
Description: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
Alias: APOBEC3, apolipoprotein B editing enzyme catalytic polypeptide-like 3C
Species: cat

Top Publications

  1. Munk C, Zielonka J, Constabel H, Kloke B, Rengstl B, Battenberg M, et al. Multiple restrictions of human immunodeficiency virus type 1 in feline cells. J Virol. 2007;81:7048-60 pubmed
    ..CrFK cells express at least three different APOBEC3s: APOBEC3C, APOBEC3H, and APOBEC3CH...
  2. M nk C, Beck T, Zielonka J, Hotz Wagenblatt A, Chareza S, Battenberg M, et al. Functions, structure, and read-through alternative splicing of feline APOBEC3 genes. Genome Biol. 2008;9:R48 pubmed publisher
    ..Among these host-encoded restriction factors, the APOBEC3 (A3; apolipoprotein B mRNA-editing catalytic polypeptide 3) proteins are potent inhibitors of retroviruses and ..
  3. Chareza S, Slavkovic Lukic D, Liu Y, Räthe A, Munk C, Zabogli E, et al. Molecular and functional interactions of cat APOBEC3 and feline foamy and immunodeficiency virus proteins: different ways to counteract host-encoded restriction. Virology. 2012;424:138-46 pubmed publisher
    Defined host-encoded feline APOBEC3 (feA3) cytidine deaminases efficiently restrict the replication and spread of exogenous retroviruses like Feline Immunodeficiency Virus (FIV) and Feline Foamy Virus (FFV) which developed different feA3 ..
  4. Lochelt M, Romen F, Bastone P, Muckenfuss H, Kirchner N, Kim Y, et al. The antiretroviral activity of APOBEC3 is inhibited by the foamy virus accessory Bet protein. Proc Natl Acad Sci U S A. 2005;102:7982-7 pubmed
    Genome hypermutation of different orthoretroviruses by cellular cytidine deaminases of the APOBEC3 family during reverse transcription has recently been observed...
  5. Lukic D, Hotz Wagenblatt A, Lei J, R the A, M hle M, Denner J, et al. Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction. Retrovirology. 2013;10:76 pubmed publisher
    b>APOBEC3 (A3) proteins restrict viral replication by cytidine deamination of viral DNA genomes and impairing reverse transcription and integration...
  6. Yoshikawa R, Nakano Y, Yamada E, Izumi T, Misawa N, Koyanagi Y, et al. Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins. Microbiol Immunol. 2016;60:272-9 pubmed publisher
    ..of cellular and viral proteins, particularly apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) and viral infectivity factor (Vif)...
  7. Zhang Z, Gu Q, Jaguva Vasudevan A, Hain A, Kloke B, Hasheminasab S, et al. Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors. Retrovirology. 2016;13:46 pubmed publisher
    ..In felids such as the domestic cat (Felis catus), APOBEC3 (A3) genes encode for single-domain A3Z2s, A3Z3 and double-domain A3Z2Z3 anti-viral cytidine deaminases...
  8. Yoshikawa R, Takeuchi J, Yamada E, Nakano Y, Misawa N, Kimura Y, et al. Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3. J Virol. 2017;91: pubmed publisher
    ..Mammalian genes encode apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins, which act as intrinsic restriction factors against lentiviruses...