Gene Symbol: PRA1
Species: Candida albicans SC5314
Marcil A, Gadoury C, Ash J, Zhang J, Nantel A, Whiteway M. Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions. Infect Immun. 2008;76:4345-58 pubmed publisher
..However, a pra1 null mutant was still able to bind fibrinogen, showing that Pra1p is not uniquely required for fibrinogen binding...
Losse J, Svobodov E, Heyken A, Hube B, Zipfel P, J zsi M. Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils. Mol Immunol. 2011;48:2135-43 pubmed publisher
..The pH-regulated antigen 1 (Pra1) of C. albicans is a surface-associated and secreted protein highly expressed in the hyphal form...
Luo S, Poltermann S, Kunert A, Rupp S, Zipfel P. Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein. Mol Immunol. 2009;47:541-50 pubmed publisher
..By screening a C. albicans cDNA expression library, we identified the pH-regulated antigen 1 (Pra1) as a novel Factor H and FHL-1 binding protein...
Luo S, Hartmann A, Dahse H, Skerka C, Zipfel P. Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3. J Immunol. 2010;185:2164-73 pubmed publisher
..albicans. The fungus secretes a potent complement inhibitor, pH-regulated Ag 1 (Pra1), which in the direct surrounding of the pathogen binds to fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, ..
Soloviev D, Jawhara S, Fonzi W. Regulation of innate immune response to Candida albicans infections by ?M?2-Pra1p interaction. Infect Immun. 2011;79:1546-58 pubmed publisher
..Thus, recognition of pH-regulated antigen 1 protein (Pra1p) by ?(M)?? plays a pivotal role in determining fungal virulence and host response and protection against C...
Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, et al
. The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol. 2018;93:266-277 pubmed publisher
..Here, we identified Pra1, the pH-regulated C...