PRA1

Summary

Gene Symbol: PRA1
Description: Pra1p
Alias: Pra1p
Species: Candida albicans SC5314

Top Publications

  1. Marcil A, Gadoury C, Ash J, Zhang J, Nantel A, Whiteway M. Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions. Infect Immun. 2008;76:4345-58 pubmed publisher
    ..However, a pra1 null mutant was still able to bind fibrinogen, showing that Pra1p is not uniquely required for fibrinogen binding...
  2. Losse J, Svobodov E, Heyken A, Hube B, Zipfel P, J zsi M. Role of pH-regulated antigen 1 of Candida albicans in the fungal recognition and antifungal response of human neutrophils. Mol Immunol. 2011;48:2135-43 pubmed publisher
    ..The pH-regulated antigen 1 (Pra1) of C. albicans is a surface-associated and secreted protein highly expressed in the hyphal form...
  3. Luo S, Poltermann S, Kunert A, Rupp S, Zipfel P. Immune evasion of the human pathogenic yeast Candida albicans: Pra1 is a Factor H, FHL-1 and plasminogen binding surface protein. Mol Immunol. 2009;47:541-50 pubmed publisher
    ..By screening a C. albicans cDNA expression library, we identified the pH-regulated antigen 1 (Pra1) as a novel Factor H and FHL-1 binding protein...
  4. Luo S, Hartmann A, Dahse H, Skerka C, Zipfel P. Secreted pH-regulated antigen 1 of Candida albicans blocks activation and conversion of complement C3. J Immunol. 2010;185:2164-73 pubmed publisher
    ..albicans. The fungus secretes a potent complement inhibitor, pH-regulated Ag 1 (Pra1), which in the direct surrounding of the pathogen binds to fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, ..
  5. Soloviev D, Jawhara S, Fonzi W. Regulation of innate immune response to Candida albicans infections by ?M?2-Pra1p interaction. Infect Immun. 2011;79:1546-58 pubmed publisher
    ..Thus, recognition of pH-regulated antigen 1 protein (Pra1p) by ?(M)?? plays a pivotal role in determining fungal virulence and host response and protection against C...
  6. Luo S, Dasari P, Reiher N, Hartmann A, Jacksch S, Wende E, et al. The secreted Candida albicans protein Pra1 disrupts host defense by broadly targeting and blocking complement C3 and C3 activation fragments. Mol Immunol. 2018;93:266-277 pubmed publisher
    ..Here, we identified Pra1, the pH-regulated C...