Gene Symbol: zyg-11
Description: Early embryogenesis protein zyg-11
Alias: Early embryogenesis protein zyg-11
Species: Caenorhabditis elegans
Kemphues K, Kusch M, Wolf N. Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans. Genetics. 1988;120:977-86 pubmed
..If our interpretation is correct, we are near saturation for pure maternal genes in the region of LG II balanced by mnC1. We conclude that the number of pure maternal genes in C. elegans is small, being probably not much higher than 12. ..
Sonneville R, GONCZY P. Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans. Development. 2004;131:3527-43 pubmed
Liu J, Vasudevan S, Kipreos E. CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans. Development. 2004;131:3513-25 pubmed
..Finally, we show that inactivation of the leucine-rich repeat protein ZYG-11 produces meiotic and polarity reversal defects similar to those observed in cul-2 mutants, suggesting that the two proteins function in the same pathways. ..
Starostina N, Lim J, Schvarzstein M, Wells L, Spence A, Kipreos E. A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination. Dev Cell. 2007;13:127-39 pubmed
..This work demonstrates that the terminal step in C. elegans sex determination is controlled by ubiquitin-mediated proteolysis. ..
Carter P, Roos J, Kemphues K. Molecular analysis of zyg-11, a maternal-effect gene required for early embryogenesis of Caenorhabditis elegans. Mol Gen Genet. 1990;221:72-80 pubmed
..A transcriptional analysis shows that transcription of the gene is not limited to the female germ-line, despite the strict maternal-effect phenotype of zyg-11 mutations. ..
Shirayama M, Soto M, Ishidate T, Kim S, Nakamura K, Bei Y, et al
. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol. 2006;16:47-55 pubmed
Vasudevan S, Starostina N, Kipreos E. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. EMBO Rep. 2007;8:279-86 pubmed
..We show that the ZYG11 gene family encompasses two main branches in metazoa, and provide evidence that members of the extended ZYG11 family in nematodes and humans are conserved components of CUL2-based ubiquitin-ligases. ..
Balachandran R, Heighington C, Starostina N, Anderson J, Owen D, Vasudevan S, et al
. The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage. J Cell Biol. 2016;215:151-166 pubmed
..We show that ZYG11A/B subunit knockdown, or broad cullin-RING ubiquitin ligase inactivation with the small molecule MLN4924, inhibits mitotic slippage in human cells, suggesting the potential for antimitotic combination therapy. ..