Gene Symbol: zyg-1
Description: Probable serine/threonine-protein kinase zyg-1
Alias: Probable serine/threonine-protein kinase zyg-1
Species: Caenorhabditis elegans

Top Publications

  1. Essex A, Dammermann A, Lewellyn L, Oegema K, Desai A. Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches. Mol Biol Cell. 2009;20:1252-67 pubmed publisher
    ..We discuss the rationale for a bipartite checkpoint mechanism in which a core Mad1(MDF-1)/Mad2(MDF-2) signal generated at kinetochores is integrated with a separate cytoplasmic Mad3(SAN-1)/BUB-3-based pathway. ..
  2. Kitagawa D, Busso C, Flückiger I, GONCZY P. Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos. Dev Cell. 2009;17:900-7 pubmed publisher
    ..Overall, our findings establish that phosphorylation of the evolutionarily conserved protein SAS-6 is critical for centriole formation and thus for faithful cell division...
  3. Wolf B, Balestra F, Spahr A, Gönczy P. ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage. Dev Biol. 2018;434:221-230 pubmed publisher
    ..These findings lead us to conclude that ZYG-1 promotes limited centriole amplification solely during the symmetric division in the C. elegans seam lineage. ..
  4. Shimanovskaya E, Viscardi V, Lesigang J, Lettman M, Qiao R, Svergun D, et al. Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases. Structure. 2014;22:1090-1104 pubmed publisher
    ..Overall, our findings suggest a conserved mechanism for centriolar docking of Plk4 homologs that initiate daughter centriole assembly. ..
  5. Kemphues K, Kusch M, Wolf N. Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans. Genetics. 1988;120:977-86 pubmed
    ..If our interpretation is correct, we are near saturation for pure maternal genes in the region of LG II balanced by mnC1. We conclude that the number of pure maternal genes in C. elegans is small, being probably not much higher than 12. ..
  6. Kemp C, Song M, Addepalli M, Hunter G, O CONNELL K. Suppressors of zyg-1 define regulators of centrosome duplication and nuclear association in Caenorhabditis elegans. Genetics. 2007;176:95-113 pubmed
    ..Our approach has thus identified numerous candidate regulators of centrosome duplication and uncovered an unanticipated regulatory mechanism involving factors that tether the centrosome to the nucleus. ..
  7. Gassmann R, Essex A, Hu J, Maddox P, Motegi F, Sugimoto A, et al. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008;22:2385-99 pubmed publisher
  8. Song M, Aravind L, MULLER REICHERT T, O Connell K. The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. Dev Cell. 2008;15:901-12 pubmed publisher
    ..Our results describe a pathway that determines centrosome size and implicate centriole duplication factors in this process. ..
  9. Peters N, Perez D, Song M, Liu Y, MULLER REICHERT T, Caron C, et al. Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1. J Cell Sci. 2010;123:795-805 pubmed publisher
    ..Our data reveal differences in the regulation of mitotic and meiotic centrosome duplication, particularly with regard to ZYG-1 activity, and reveal an important role for centrosomes in spermatid formation...

More Information


  1. O Connell K, Caron C, Kopish K, Hurd D, Kemphues K, Li Y, et al. The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo. Cell. 2001;105:547-58 pubmed
    ..ZYG-1 is therefore a key molecular component of the centrosome/centriole duplication process. ..
  2. O Connell K, Leys C, White J. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans. Genetics. 1998;149:1303-21 pubmed
    ..We conclude that this approach can be used to identify mutations that affect various aspects of the cell-division cycle. ..
  3. Leidel S, Delattre M, Cerutti L, Baumer K, GONCZY P. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nat Cell Biol. 2005;7:115-25 pubmed
    ..Therefore, HsSAS-6 is also required for centrosome duplication, indicating that the function of SAS-6-related proteins has been widely conserved during evolution. ..
  4. Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
    ..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
  5. Ródenas E, González Aguilera C, Ayuso C, Askjaer P. Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans. Mol Biol Cell. 2012;23:930-44 pubmed publisher
    ..Thus our results strengthen the emerging connection between nuclear pore proteins and chromosome segregation. ..
  6. Lettman M, Wong Y, Viscardi V, Niessen S, Chen S, Shiau A, et al. Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly. Dev Cell. 2013;25:284-98 pubmed publisher
    ..We propose that ZYG-1 binding to the SAS-6 coiled coil recruits the SAS-6-SAS-5 complex to the mother centriole, where a ZYG-1 kinase activity-dependent step, whose target is unlikely to be SAS-6, triggers cartwheel assembly. ..
  7. Stubenvoll M, Medley J, Irwin M, Song M. ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. PLoS Genet. 2016;12:e1006370 pubmed publisher
    ..Our data suggest that RNA-binding proteins play an active role in controlling MT dynamics and provide insight into the control of proper centrosome size and MT dynamics. ..
  8. Dammermann A, MULLER REICHERT T, Pelletier L, Habermann B, Desai A, Oegema K. Centriole assembly requires both centriolar and pericentriolar material proteins. Dev Cell. 2004;7:815-29 pubmed
    ..Thus, both centriolar and pericentriolar material proteins contribute to centriole assembly. ..
  9. Peel N, Dougherty M, Goeres J, Liu Y, O Connell K. The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels. J Cell Sci. 2012;125:3535-44 pubmed
    ..Co-depletion of LIN-23 and SEL-10 suggests these proteins function cooperatively. Because SEL-10 is the homolog of human FBW7, which is frequently mutated in cancer, our findings have implications for understanding tumorigenesis...