Gene Symbol: xbp-1
Description: X-box Binding Protein homolog
Alias: X-box Binding Protein homolog
Species: Caenorhabditis elegans

Top Publications

  1. Calfon M, Zeng H, Urano F, Till J, Hubbard S, Harding H, et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 2002;415:92-6 pubmed
    ..Our findings suggest that physiological ER load regulates a developmental decision in higher eukaryotes. ..
  2. Henis Korenblit S, Zhang P, Hansen M, McCormick M, Lee S, Cary M, et al. Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity. Proc Natl Acad Sci U S A. 2010;107:9730-5 pubmed publisher
    ..Instead, in insulin/IGF-1 pathway mutants, XBP-1 collaborates with DAF-16, a FOXO-transcription factor that is activated in these mutants, to enhance ER stress resistance and to activate new genes that promote longevity. ..
  3. Chen D, Thomas E, Kapahi P. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet. 2009;5:e1000486 pubmed publisher
    ..Therefore, our results demonstrate a tissue-specific role for HIF-1 in the lifespan extension by DR involving the IRE-1 ER stress pathway. ..
  4. Shen X, Ellis R, Lee K, Liu C, Yang K, Solomon A, et al. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell. 2001;107:893-903 pubmed
    ..We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis. The results demonstrate that the UPR and ER homeostasis are essential for metazoan development. ..
  5. Shen X, Ellis R, Sakaki K, Kaufman R. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. PLoS Genet. 2005;1:e37 pubmed
    ..Finally, our array study identified the liver-specific transcription factor CREBh as a novel UPR gene conserved during metazoan evolution. ..
  6. Richardson C, Kooistra T, Kim D. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature. 2010;463:1092-5 pubmed publisher
    ..elegans development and indicate that an ancient, conserved role for XBP-1 may be to protect the host organism from the detrimental effects of mounting an innate immune response to microbes. ..
  7. Richardson C, Kinkel S, Kim D. Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity. PLoS Genet. 2011;7:e1002391 pubmed publisher
  8. Kapulkin W, Kapulkin V, Hiester B, Link C. Compensatory regulation among ER chaperones in C. elegans. FEBS Lett. 2005;579:3063-8 pubmed
    ..We show that this compensatory regulation is specific for ER chaperones, not dependent on RNA interference, and required for maintaining viability in worms containing a deletion of the hsp-3 gene. ..
  9. Sun J, Liu Y, Aballay A. Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. EMBO Rep. 2012;13:855-60 pubmed publisher
    ..Our results indicate that the nervous system temporally controls the UPR pathway to maintain ER homeostasis during development and immune activation. ..

More Information


  1. Mao X, Crowder C. Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery. Mol Cell Biol. 2010;30:5033-42 pubmed publisher
    ..These data suggest a model where hypoxia-induced misfolded proteins trigger the activation of IRE-1, which along with GCN-2 controls an adaptive response that is essential to HP. ..
  2. Shim J, Umemura T, Nothstein E, Rongo C. The unfolded protein response regulates glutamate receptor export from the endoplasmic reticulum. Mol Biol Cell. 2004;15:4818-28 pubmed
    ..Expression of XBP-1, a component of the UPR pathway, is elevated in neurons during development. Our results suggest that UPR signaling is a critical step in neural function that is needed for glutamate receptor assembly and secretion. ..
  3. Taylor R, Dillin A. XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity. Cell. 2013;153:1435-47 pubmed publisher
    ..Our findings point toward a secreted ER stress signal (SERSS) that promotes ER stress resistance and longevity. ..
  4. Glover Cutter K, Lin S, Blackwell T. Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf. PLoS Genet. 2013;9:e1003701 pubmed publisher
    ..Regulatory integration through SKN-1/Nrf may coordinate ER and cytoplasmic homeostasis. ..
  5. Guo B, Huang X, Zhang P, Qi L, Liang Q, Zhang X, et al. Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development. EMBO Rep. 2014;15:705-13 pubmed publisher
    ..Our study thus provides a framework for understanding the role of signaling pathways in regulating autophagy under physiological conditions. ..
  6. Lee D, Singaravelu G, Park B, Ahnn J. Differential requirement of unfolded protein response pathway for calreticulin expression in Caenorhabditis elegans. J Mol Biol. 2007;372:331-40 pubmed
  7. Eisermann D, Wenzel U, Fitzenberger E. PEK-1 is crucial for hormesis induced by inhibition of the IRE-1/XBP-1 pathway in the Caenorhabditis elegans mev-1 mutant. Biochem Biophys Res Commun. 2016;473:1052-1057 pubmed publisher
    ..In conclusion, we identified PEK-1 as a mediator of hormesis in the mev-1 mutant of C. elegans which is induced by simultaneous inhibition of XBP-1 and its splicing activator IRE-1 and mediated through activation of the proteasome. ..
  8. Mark K, Dumas K, Bhaumik D, Schilling B, Davis S, Oron T, et al. Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep. 2016;17:1227-1237 pubmed publisher
  9. Lim Y, Lee D, Kalichamy K, Hong S, Michalak M, Ahnn J, et al. Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans. Int J Biochem Cell Biol. 2014;53:399-408 pubmed publisher
    ..Our results suggest that sumoylation plays a regulatory role in ER function by controlling the expression of genes required for ER homeostasis in C. elegans...
  10. Brokate Llanos A, Monje J, Murdoch P, Muñoz M. Developmental defects in a Caenorhabditis elegans model for type III galactosemia. Genetics. 2014;198:1559-69 pubmed publisher
    ..We also observed that gale-1 mutants are hypersensitive to galactose as well as to infections. Interestingly, we found interactions between gale-1 and the unfolded protein response. ..
  11. Ray A, Zhang S, Rentas C, Caldwell K, Caldwell G. RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway. J Neurosci. 2014;34:16076-85 pubmed publisher
    ..Collectively, these studies highlight the mechanistic intersection of RNA processing and proteostasis in mediating neuroprotection. ..