Gene Symbol: wwp-1
Description: E3 ubiquitin-protein ligase;WW domain Protein (E3 ubiquitin ligase)
Alias: E3 ubiquitin-protein ligase;WW domain Protein (E3 ubiquitin ligase)
Species: Caenorhabditis elegans
Huang K, Johnson K, Petcherski A, Vandergon T, Mosser E, Copeland N, et al
. A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000;252:137-45 pubmed
..CeWWP1 must therefore have unique and nonredundant functions critical for embryogenesis. ..
Carrano A, Liu Z, Dillin A, Hunter T. A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature. 2009;460:396-9 pubmed publisher
..Taken together, our results indicate that WWP-1 and UBC-18 function to ubiquitinate substrates that regulate diet-restriction-induced longevity. ..
Shaye D, Greenwald I. LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. Development. 2005;132:5081-92 pubmed
Astin J, O Neil N, Kuwabara P. Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1. DNA Repair (Amst). 2008;7:267-80 pubmed
..The absence of wwp-1 by itself does not cause sensitivity to UV irradiation, but it acts synergistically with a mutation in xpa-1 to enhance UV hypersensitivity. ..
Chen C, Bellier A, Kao C, Yang Y, Chen H, Los F, et al
. WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans. PLoS ONE. 2010;5:e9494 pubmed publisher
..Taken together, our data suggest that WWP-1 and DAF-16 function in parallel within the fundamental DAF-2 insulin/IGF-1 signaling network to regulate fundamental cellular responses in C. elegans. ..
Wang R, Kaul Z, Ambardekar C, Yamamoto T, Kavdia K, Kodali K, et al
. HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans. Development. 2013;140:2149-59 pubmed publisher
..Our study reports a novel mechanism, mediated by ETC-1, that co-operates with APC/C to maintain the meiotic arrest required for proper cell cycle timing during reproduction. ..
Carrano A, Dillin A, Hunter T. A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. Nat Commun. 2014;5:3772 pubmed publisher
..Our data support a model in which modulation of KLF-1 by WWP-1 regulates diet-restriction-induced longevity. ..