wee-1.3

Summary

Gene Symbol: wee-1.3
Description: Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase wee-1.3
Alias: Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase wee-1.3
Species: Caenorhabditis elegans

Top Publications

  1. Detwiler M, Reuben M, Li X, Rogers E, Lin R. Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans. Dev Cell. 2001;1:187-99 pubmed
    ..The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation. ..
  2. Lamitina S, L hernault S. Dominant mutations in the Caenorhabditis elegans Myt1 ortholog wee-1.3 reveal a novel domain that controls M-phase entry during spermatogenesis. Development. 2002;129:5009-18 pubmed
    ..This suggests that a novel, sperm-specific pathway negatively regulates WEE-1.3 to allow the G2/M transition of male meiosis I, and that dominant wee-1.3 mutants prevent this negative regulation. ..
  3. Burrows A, Sceurman B, Kosinski M, Richie C, Sadler P, Schumacher J, et al. The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Development. 2006;133:697-709 pubmed
    ..Furthermore, co-depletion studies of CDK-1 and WEE-1.3 demonstrate that WEE-1.3 is dispensable in the absence of CDK-1, suggesting that CDK-1 is a major target of WEE-1.3 in C. elegans oocytes. ..
  4. Stitzel M, Pellettieri J, Seydoux G. The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation. Curr Biol. 2006;16:56-62 pubmed
    ..Our findings suggest that regulators of meiotic M phase activate a remodeling program, independently of fertilization, to prepare eggs for embryogenesis. ..
  5. Inoue T, Hirata K, Kuwana Y, Fujita M, Miwa J, Roy R, et al. Cell cycle control by daf-21/Hsp90 at the first meiotic prophase/metaphase boundary during oogenesis in Caenorhabditis elegans. Dev Growth Differ. 2006;48:25-32 pubmed
    ..3. Thus, all together, we propose that DAF-21 indirectly regulates the meiotic prophase/metaphase transition during oocyte development by ensuring the normal function of WEE-1.3. ..
  6. Yoon S, Kawasaki I, Shim Y. CDC-25.1 controls the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively regulating CDK-1 in Caenorhabditis elegans. Cell Cycle. 2012;11:1354-63 pubmed publisher
    ..We propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively controlling CDK-1, which forms a complex primarily with CYB-3, but also possibly with CYD-1 and CYE-1. ..
  7. Allen A, Nesmith J, Golden A. An RNAi-based suppressor screen identifies interactors of the Myt1 ortholog of Caenorhabditis elegans. G3 (Bethesda). 2014;4:2329-43 pubmed publisher
    ..The suppressors include many previously unidentified players in the meiotic cell cycle and represent a pool of potential WEE-1.3 interacting proteins that function during C. elegans oocyte maturation and zygotic development. ..