Gene Symbol: wee-1.3
Description: Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase wee-1.3
Alias: Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase wee-1.3
Species: Caenorhabditis elegans
Detwiler M, Reuben M, Li X, Rogers E, Lin R. Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans. Dev Cell. 2001;1:187-99 pubmed
..The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation. ..
Lamitina S, L hernault S. Dominant mutations in the Caenorhabditis elegans Myt1 ortholog wee-1.3 reveal a novel domain that controls M-phase entry during spermatogenesis. Development. 2002;129:5009-18 pubmed
..This suggests that a novel, sperm-specific pathway negatively regulates WEE-1.3 to allow the G2/M transition of male meiosis I, and that dominant wee-1.3 mutants prevent this negative regulation. ..
Burrows A, Sceurman B, Kosinski M, Richie C, Sadler P, Schumacher J, et al
. The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Development. 2006;133:697-709 pubmed
..Furthermore, co-depletion studies of CDK-1 and WEE-1.3 demonstrate that WEE-1.3 is dispensable in the absence of CDK-1, suggesting that CDK-1 is a major target of WEE-1.3 in C. elegans oocytes. ..
Stitzel M, Pellettieri J, Seydoux G. The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation. Curr Biol. 2006;16:56-62 pubmed
..Our findings suggest that regulators of meiotic M phase activate a remodeling program, independently of fertilization, to prepare eggs for embryogenesis. ..
Inoue T, Hirata K, Kuwana Y, Fujita M, Miwa J, Roy R, et al
. Cell cycle control by daf-21/Hsp90 at the first meiotic prophase/metaphase boundary during oogenesis in Caenorhabditis elegans. Dev Growth Differ. 2006;48:25-32 pubmed
..3. Thus, all together, we propose that DAF-21 indirectly regulates the meiotic prophase/metaphase transition during oocyte development by ensuring the normal function of WEE-1.3. ..
Yoon S, Kawasaki I, Shim Y. CDC-25.1 controls the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively regulating CDK-1 in Caenorhabditis elegans. Cell Cycle. 2012;11:1354-63 pubmed publisher
..We propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE-1.3 and by positively controlling CDK-1, which forms a complex primarily with CYB-3, but also possibly with CYD-1 and CYE-1. ..
Allen A, Nesmith J, Golden A. An RNAi-based suppressor screen identifies interactors of the Myt1 ortholog of Caenorhabditis elegans. G3 (Bethesda). 2014;4:2329-43 pubmed publisher
..The suppressors include many previously unidentified players in the meiotic cell cycle and represent a pool of potential WEE-1.3 interacting proteins that function during C. elegans oocyte maturation and zygotic development. ..