Gene Symbol: wdr-23
Description: DDB1-and CUL4-associated factor 11 homolog;WD Repeat protein
Alias: DDB1-and CUL4-associated factor 11 homolog;WD Repeat protein
Species: Caenorhabditis elegans
Choe K, Przybysz A, Strange K. The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Mol Cell Biol. 2009;29:2704-15 pubmed publisher
..These findings define the mechanism of SKN-1 accumulation in the cell nucleus and provide a new mechanistic framework for understanding how phosphorylation signals are integrated to regulate stress resistance and longevity. ..
Staab T, Griffen T, Corcoran C, Evgrafov O, Knowles J, Sieburth D. The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003354 pubmed publisher
..These results provide insight into how SKN-1/Nrf2 might protect the nervous system from damage in response to oxidative stress. ..
Settivari R, Vanduyn N, Levora J, Nass R. The Nrf2/SKN-1-dependent glutathione S-transferase Ï€ homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism. Neurotoxicology. 2013;38:51-60 pubmed publisher
Wu C, Deonarine A, Przybysz A, Strange K, Choe K. The Skp1 Homologs SKR-1/2 Are Required for the Caenorhabditis elegans SKN-1 Antioxidant/Detoxification Response Independently of p38 MAPK. PLoS Genet. 2016;12:e1006361 pubmed publisher
..Together, these results identify a novel p38 MAPK independent signaling mechanism that activates SKN-1 via SKR-1/2 and involves WDR-23. ..
Curran S, Ruvkun G. Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet. 2007;3:e56 pubmed
..These results suggest that insulin-signaling pathways play a role in regulation of aging at any stage in life. ..
Staab T, Evgrafov O, Egrafov O, Knowles J, Sieburth D. Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress. PLoS Genet. 2014;10:e1004100 pubmed publisher
..Together, our results suggest that SKN-1 activation in the nervous system can confer protection to organisms in response to stress by directly regulating nlg-1/neuroligin expression. ..
Tang L, Choe K. Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways. Mech Ageing Dev. 2015;149:88-98 pubmed publisher
..Lastly, genetic interaction data revise our understanding of which skn-1 variants are required for longevity during dietary restriction. ..
Wu C, Wang Y, Choe K. F-Box Protein XREP-4 Is a New Regulator of the Oxidative Stress Response in Caenorhabditis elegans. Genetics. 2017;206:859-871 pubmed publisher
..These results are consistent with XREP-4 influencing the SKN-1 stress response by functioning as a bridge between WDR-23 and the ubiquitin ligase component SKR-1. ..
Fukushige T, Smith H, Miwa J, Krause M, Hanover J. A Genetic Analysis of the Caenorhabditis elegans Detoxification Response. Genetics. 2017;206:939-952 pubmed publisher
..Epistatic relationships among the xrep mutants and their interacting partners allow us to propose an ordered genetic pathway by which endogenous and exogenous stressors induce the phase II detoxification response. ..