Gene Symbol: vhp-1
Description: Tyrosine-protein phosphatase vhp-1;VH1 dual-specificity phosphatase family
Alias: Tyrosine-protein phosphatase vhp-1;VH1 dual-specificity phosphatase family
Species: Caenorhabditis elegans
Mizuno T, Hisamoto N, Terada T, Kondo T, Adachi M, Nishida E, et al
. The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response. EMBO J. 2004;23:2226-34 pubmed
..These results suggest that VHP-1 plays a pivotal role in the integration and fine-tuning of the stress response regulated by the KGB-1 MAPK pathway. ..
Kim D, Liberati N, Mizuno T, Inoue H, Hisamoto N, Matsumoto K, et al
. Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase. Proc Natl Acad Sci U S A. 2004;101:10990-4 pubmed
..In addition, these data point to mechanisms in multicellular organisms by which signals transduced by distinct MAPK pathways may be subject to physiological integration at the level of regulation of MAPK activity by MAPKKs and MKPs. ..
Hattori A, Mizuno T, Akamatsu M, Hisamoto N, Matsumoto K. The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex. PLoS Genet. 2013;9:e1003315 pubmed publisher
..This study describes the direct link from JNK signaling, Fos phosphorylation, and regulation of kreg gene transcription, which modulates the stress response in C. elegans...
Richardson C, Kooistra T, Kim D. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature. 2010;463:1092-5 pubmed publisher
..elegans development and indicate that an ancient, conserved role for XBP-1 may be to protect the host organism from the detrimental effects of mounting an innate immune response to microbes. ..
Nix P, Hisamoto N, Matsumoto K, Bastiani M. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways. Proc Natl Acad Sci U S A. 2011;108:10738-43 pubmed publisher
..These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK). ..
Twumasi Boateng K, Wang T, Tsai L, Lee K, Salehpour A, Bhat S, et al
. An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell. 2012;11:659-67 pubmed publisher
..Furthermore, the age-dependent reversal has intriguing implications for our understanding of aging...