Gene Symbol: vha-2
Description: V-type proton ATPase 16 kDa proteolipid subunit 2/3
Alias: V-type proton ATPase 16 kDa proteolipid subunit 2/3
Species: Caenorhabditis elegans

Top Publications

  1. Syntichaki P, Samara C, Tavernarakis N. The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol. 2005;15:1249-54 pubmed
    ..Similar mechanisms may contribute to necrotic cell death that follows extreme acidosis-for example, during stroke-in humans. ..
  2. Samara C, Syntichaki P, Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ. 2008;15:105-12 pubmed
    ..Our findings demonstrate that autophagy contributes to cellular destruction during necrosis. Thus, interfering with the autophagic process may protect neurons against necrotic damage in humans. ..
  3. Troulinaki K, Tavernarakis N. Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J. 2012;31:654-66 pubmed publisher
    ..These findings demonstrate a prominent role for endocytosis in cellular destruction during neurodegeneration, which is likely conserved in metazoans. ..
  4. Oka T, Yamamoto R, Futai M. Three vha genes encode proteolipids of Caenorhabditis elegans vacuolar-type ATPase. Gene structures and preferential expression in an H-shaped excretory cell and rectal cells. J Biol Chem. 1997;272:24387-92 pubmed
    ..These results suggest that the V-ATPase activity may be important for exporting toxic compounds or metabolic wastes in this organism. ..
  5. Oka T, Yamamoto R, Futai M. Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans. A new gene, vha-3, has a distinct cell-specific distribution. J Biol Chem. 1998;273:22570-6 pubmed
    ..Expression of the vha-11 cDNA complemented a null mutation of VMA5, the yeast C subunit gene, thus demonstrating that vha-11 was the functional C subunit of C. elegans. ..
  6. Oka T, Futai M. Requirement of V-ATPase for ovulation and embryogenesis in Caenorhabditis elegans. J Biol Chem. 2000;275:29556-61 pubmed
    ..Similar results were obtained for RNA interference of the V-ATPase proteolipid genes. These results suggest that V-ATPases, and thus inside-acidic organelles, are required for ovulation and embryogenesis. ..