Gene Symbol: vha-12
Description: Probable V-type proton ATPase subunit B
Alias: Probable V-type proton ATPase subunit B
Species: Caenorhabditis elegans

Top Publications

  1. Kontani K, Moskowitz I, Rothman J. Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex. Dev Cell. 2005;8:787-94 pubmed
    ..fus-1 encodes the e subunit of the vacuolar H(+)-ATPase (V-ATPase), and loss of other V-ATPase subunits also causes widespread hyperfusion. These findings raise the possibility of manipulating cell fusion by altering V-ATPase activity. ..
  2. Syntichaki P, Samara C, Tavernarakis N. The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol. 2005;15:1249-54 pubmed
    ..Similar mechanisms may contribute to necrotic cell death that follows extreme acidosis-for example, during stroke-in humans. ..
  3. Richardson C, Kooistra T, Kim D. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature. 2010;463:1092-5 pubmed publisher
    ..elegans development and indicate that an ancient, conserved role for XBP-1 may be to protect the host organism from the detrimental effects of mounting an innate immune response to microbes. ..
  4. Kanamori T, Inoue T, Sakamoto T, Gengyo Ando K, Tsujimoto M, Mitani S, et al. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. EMBO J. 2008;27:1647-57 pubmed publisher
    ..We propose that membrane trafficking regulated by ipla-1 provides a mechanism to control the cortical asymmetry of beta-catenin. ..