Gene Symbol: vab-8
Description: Kinesin-like protein vab-8;hypothetical protein
Alias: Kinesin-like protein vab-8;hypothetical protein
Species: Caenorhabditis elegans
Manser J, Wood W. Mutations affecting embryonic cell migrations in Caenorhabditis elegans. Dev Genet. 1990;11:49-64 pubmed
..The possible nature of the mutant defects and possible roles of these four loci in cell migration are discussed. ..
Wolf F, Hung M, Wightman B, Way J, Garriga G. vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity. Neuron. 1998;20:655-66 pubmed
..We propose that regulation of vab-8 activity is a mechanism for controlling the direction of cell and axon growth cone migrations. ..
Lai T, Garriga G. The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans. Development. 2004;131:5991-6000 pubmed
..Taken together, our results suggest that VAB-8 and UNC-14 are substrates that mediate the function of UNC-51 in axon outgrowth. ..
Meng L, Chen C, Yan D. Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. PLoS Genet. 2016;12:e1005948 pubmed publisher
..Therefore, we first show a signal pathway including ankyrin, CRMP, and kinesin in regulating gap junctions. ..
Wightman B, Clark S, Taskar A, Forrester W, Maricq A, Bargmann C, et al
. The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration. Development. 1996;122:671-82 pubmed
..vab-8 encodes two genetic activities that function in the guidance of different migrations. Our results suggest that most posteriorly directed cell and growth cone migrations are guided by a common mechanism involving the vab-8 gene. ..
Pan C, Howell J, Clark S, Hilliard M, Cordes S, Bargmann C, et al
. Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Dev Cell. 2006;10:367-77 pubmed
..Our results indicate that Wnts play a key role in A/P guidance in C. elegans and employ distinct mechanisms to regulate different migrations. ..
Watari Goshima N, Ogura K, Wolf F, Goshima Y, Garriga G. C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations. Nat Neurosci. 2007;10:169-76 pubmed