Gene Symbol: vab 10
Description: hypothetical protein
Species: Caenorhabditis elegans
Kim H, Murakami R, Quintin S, Mori M, Ohkura K, Tamai K, et al
. VAB-10 spectraplakin acts in cell and nuclear migration in Caenorhabditis elegans. Development. 2011;138:4013-23 pubmed publisher
..These results suggest that VAB-10B1/spectraplakin regulates the polarized alignment of MTs, possibly by linking F-actin and MTs, which enables normal nuclear translocation and cell migration of DTCs. ..
Bosher J, Hahn B, Legouis R, Sookhareea S, Weimer R, Gansmuller A, et al
. The Caenorhabditis elegans vab-10 spectraplakin isoforms protect the epidermis against internal and external forces. J Cell Biol. 2003;161:757-68 pubmed
..In contrast, lack of VAB-10B leads to increased epidermal thickness during embryonic morphogenesis when epidermal cells change shape. We suggest that this isoform protects cells against tension that builds up within the epidermis. ..
Hetherington S, Gally C, Fritz J, Polanowska J, Reboul J, Schwab Y, et al
. PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis. Dev Biol. 2011;350:267-78 pubmed publisher
..PAT-12 defines a novel component of C. elegans hemidesmosomes, which is required for maintaining their integrity. We suggest that PAT-12 helps maintaining VAB-10 attachment with matrix receptors...
Zhang H, Landmann F, Zahreddine H, Rodriguez D, Koch M, Labouesse M. A tension-induced mechanotransduction pathway promotes epithelial morphogenesis. Nature. 2011;471:99-103 pubmed publisher
..We suggest that similar pathways could promote epithelial morphogenesis or wound healing in other organisms in which epithelial cells adhere to tension-generating contractile cells...
Morrissey M, Keeley D, Hagedorn E, McClatchey S, Chi Q, Hall D, et al
. B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes. Dev Cell. 2014;31:319-31 pubmed publisher
..Together, plakin, integrin, and hemicentin are founding components of a cell-directed adhesion system, which we name a BM-LINKage (B-LINK), that connects adjacent tissues through adjoining BMs. ..
Yang Y, Zhang Y, Li W, Jiang Y, Zhu Z, Hu H, et al
. Spectraplakin Induces Positive Feedback between Fusogens and the Actin Cytoskeleton to Promote Cell-Cell Fusion. Dev Cell. 2017;41:107-120.e4 pubmed publisher