Gene Symbol: unc-94
Description: Tropomodulin
Alias: Tropomodulin
Species: Caenorhabditis elegans

Top Publications

  1. Lu S, Symersky J, Li S, Carson M, Chen L, Meehan E, et al. Structural genomics of Caenorhabditis elegans: crystal structure of the tropomodulin C-terminal domain. Proteins. 2004;56:384-6 pubmed
  2. Stevenson T, Mercer K, Cox E, Szewczyk N, Conley C, HARDIN J, et al. unc-94 encodes a tropomodulin in Caenorhabditis elegans. J Mol Biol. 2007;374:936-50 pubmed
    ..Multiple lines of evidence prove that unc-94 encodes a tropomodulin, a conserved protein known from other systems to bind to both actin and tropomyosin at the pointed ends of ..
  3. Yamashiro S, Cox E, Baillie D, Hardin J, Ono S. Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans. J Cell Sci. 2008;121:3867-77 pubmed publisher
    ..Sarcomeric actin filaments are uniform in their lengths and regularly arranged in a striated pattern. Tropomodulin caps the pointed end of actin filaments and is a crucial regulator of sarcomere assembly...
  4. Cox Paulson E, Walck Shannon E, Lynch A, Yamashiro S, Zaidel Bar R, Eno C, et al. Tropomodulin protects ?-catenin-dependent junctional-actin networks under stress during epithelial morphogenesis. Curr Biol. 2012;22:1500-5 pubmed publisher
    ..elegans ?-catenin, hmp-1, thereby identifying UNC-94/tropomodulin. Tropomodulins (Tmods) cap the minus ends of F-actin in sarcomeres...
  5. Cox Paulson E, Cannataro V, Gallagher T, Hoffman C, Mantione G, McIntosh M, et al. The minus-end actin capping protein, UNC-94/tropomodulin, regulates development of the Caenorhabditis elegans intestine. Dev Dyn. 2014;243:753-64 pubmed publisher
    ..The C. elegans tropomodulin homolog, UNC-94, has sequence and functional similarity to vertebrate tropomodulins...
  6. Ding H, Qiu S, Bunzel R, Luo D, Arabashi A, Lu S, et al. Purification, nanocrystallization and preliminary X-ray analysis of a C-terminal part of tropomodulin protein 1, isoform A, from Caenorhabditis elegans. Acta Crystallogr D Biol Crystallogr. 2003;59:1106-8 pubmed
    The C-terminal part of tropomodulin protein 1, isoform A, from Caenorhabditis elegans was expressed in Escherichia coli and purified to homogeneity. Optimized from the initial nanoscreen, crystals grew to dimensions of 0.25 x 0.15 x 0...