Gene Symbol: unc-86
Description: Transcription factor unc-86
Alias: Transcription factor unc-86
Species: Caenorhabditis elegans

Top Publications

  1. Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427:645-9 pubmed
    ..Thus, ERI-1 is a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference. ..
  2. Desai C, Garriga G, McIntire S, Horvitz H. A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature. 1988;336:638-46 pubmed
    ..Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types. ..
  3. Massirer K, Perez S, Mondol V, Pasquinelli A. The miR-35-41 family of microRNAs regulates RNAi sensitivity in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002536 pubmed publisher
    ..Our results reveal that miRNAs can broadly regulate other small RNA pathways and, thus, have far reaching effects on gene expression beyond directly targeting specific mRNAs. ..
  4. Finney M, Ruvkun G. The unc-86 gene product couples cell lineage and cell identity in C. elegans. Cell. 1990;63:895-905 pubmed
    ..unc-86 protein also appears shortly after cell division in the nuclei of particular identified differentiating neurons; at least some of these neurons are nonfunctional in unc-86 mutants. ..
  5. Chalfie M, Sulston J. Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans. Dev Biol. 1981;82:358-70 pubmed
  6. Zhang F, Bhattacharya A, Nelson J, Abe N, Gordon P, Lloret Fernández C, et al. The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types. Development. 2014;141:422-35 pubmed publisher
    ..In conclusion, transcription factors operate as terminal selectors in distinct combinations in different neuron types, defining neuron type-specific identity features...
  7. Duggan A, Ma C, Chalfie M. Regulation of touch receptor differentiation by the Caenorhabditis elegans mec-3 and unc-86 genes. Development. 1998;125:4107-19 pubmed
    ..In the modification of UNC-86 function by MEC-3 in the touch cells, these studies provide an example of how the sequential activation of transcription factors can determine cell fate within particular cell lineages. ..
  8. Xue D, Finney M, Ruvkun G, Chalfie M. Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3. EMBO J. 1992;11:4969-79 pubmed
    ..Interestingly, the unc-86 gene appears to be required not only to initiate mec-3 expression but also to maintain it. ..
  9. Hodgkin J, Horvitz H, Brenner S. Nondisjunction Mutants of the Nematode CAENORHABDITIS ELEGANS. Genetics. 1979;91:67-94 pubmed
    ..Haplo-X and diplo-X ova are produced in 2:1 ratio by 3X hermaphrodites. him mutations are expressed in these animals, increasing the frequency of self-progeny males and 2X hermaphrodites. ..

More Information


  1. Horvitz H, Sulston J. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics. 1980;96:435-54 pubmed
    ..Three of the mutants are suppressed by pleiotropic suppressors believed to be specific for null alleles, suggesting that their phenotypes result from the complete absence of gene activity. ..
  2. Mitani S, Du H, Hall D, Driscoll M, Chalfie M. Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development. 1993;119:773-83 pubmed
  3. Peden E, Kimberly E, Gengyo Ando K, Mitani S, Xue D. Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes Dev. 2007;21:3195-207 pubmed
  4. Shaham S, Bargmann C. Control of neuronal subtype identity by the C. elegans ARID protein CFI-1. Genes Dev. 2002;16:972-83 pubmed
    ..ARID proteins regulate early patterning and muscle fate in Drosophila, but they have not previously been implicated in the control of neuronal subtype identity. ..
  5. Olsson Carter K, Slack F. The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth. Dev Dyn. 2011;240:1815-25 pubmed publisher
    ..This temporal shift is not dependent on UNC-40 or SAX-3, and does not require the presence of lin-4. We propose that unc-86(lf) HSN axons are misguided due to the temporal decoupling of axon initiation and ventral guidance responses. ..
  6. Sze J, Ruvkun G. Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A. 2003;100:9560-5 pubmed
  7. Wang L, Way J. Promoter sequences for the establishment of mec-3 expression in the nematode Caenorhabditis elegans. Mech Dev. 1996;56:183-96 pubmed
    ..Adjacent to the UNC-86 recognition site is an additional sequence that is important for establishment of mec-3 expression and is presumably recognized by an unidentified transcription factor. ..
  8. Lichtsteiner S, Tjian R. Synergistic activation of transcription by UNC-86 and MEC-3 in Caenorhabditis elegans embryo extracts. EMBO J. 1995;14:3937-45 pubmed
    ..These studies provide direct functional evidence for coordinated transcriptional activation by two C.elegans DNA binding proteins that have been defined genetically as regulators of gene expression during embryogenesis. ..
  9. Gordon P, Hobert O. A competition mechanism for a homeotic neuron identity transformation in C. elegans. Dev Cell. 2015;34:206-19 pubmed publisher
    ..Homeotic control of neuronal identity programs has implications for the evolution of neuronal cell types. ..