Gene Symbol: unc-84
Description: Nuclear migration and anchoring protein unc-84
Alias: Nuclear migration and anchoring protein unc-84
Species: Caenorhabditis elegans
Products:     unc-84

Top Publications

  1. Sulston J, Horvitz H. Abnormal cell lineages in mutants of the nematode Caenorhabditis elegans. Dev Biol. 1981;82:41-55 pubmed
  2. Horvitz H, Sulston J. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics. 1980;96:435-54 pubmed
    ..Three of the mutants are suppressed by pleiotropic suppressors believed to be specific for null alleles, suggesting that their phenotypes result from the complete absence of gene activity. ..
  3. Malone C, Fixsen W, Horvitz H, Han M. UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development. Development. 1999;126:3171-81 pubmed
    ..We propose that UNC-84 functions to facilitate a nuclear-centrosomal interaction required for nuclear migration and anchorage. ..
  4. McGee M, Rillo R, Anderson A, Starr D. UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84. Mol Biol Cell. 2006;17:1790-801 pubmed
    ..This mechanism seems conserved across eukaryotes and is the first proposed mechanism to target proteins specifically to the outer nuclear membrane. ..
  5. Starr D, Hermann G, Malone C, Fixsen W, Priess J, Horvitz H, et al. unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development. 2001;128:5039-50 pubmed
    ..We favor a model in which UNC-84 directly recruits UNC-83 to the nuclear envelope where they help transfer force between the cytoskeleton and the nucleus...
  6. Lee K, Starr D, Cohen M, Liu J, Han M, Wilson K, et al. Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol Biol Cell. 2002;13:892-901 pubmed
    ..UNC-84 is not required for centrosome attachment to the nucleus because centrosomes are localized normally in unc-84 hyp7 cells despite a nuclear migration defect. Models for UNC-84 localization are discussed. ..
  7. Tapley E, Ly N, Starr D. Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane. Mol Biol Cell. 2011;22:1739-52 pubmed publisher
    ..Multiple mechanisms might also be used to target other proteins to the INM, thereby ensuring their proper and timely localization for essential cellular and developmental functions. ..
  8. Hedgecock E, Culotti J, Hall D, Stern B. Genetics of cell and axon migrations in Caenorhabditis elegans. Development. 1987;100:365-82 pubmed
    ..The first muscles and neurones may in turn express new surface molecules that refine later cell movements. Mutations in some 30 known genes disrupt the movements of cells or axons along the body wall. ..
  9. Xiong H, Mohler W, Soto M. The branched actin nucleator Arp2/3 promotes nuclear migrations and cell polarity in the C. elegans zygote. Dev Biol. 2011;357:356-69 pubmed publisher
    ..In contrast with previous studies emphasizing pulling forces on the male pronucleus, we propose that robust MT nucleation pushes the male pronucleus anteriorly to join the female pronucleus...

More Information


  1. Cain N, Tapley E, McDonald K, Cain B, Starr D. The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture. J Cell Biol. 2014;206:163-72 pubmed publisher
    ..Therefore, SUN-KASH bridges are only required to maintain NE spacing in cells subjected to increased mechanical forces. Furthermore, SUN proteins do not dictate the width of the NE. ..
  2. Bone C, Tapley E, Gorjanacz M, Starr D. The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration. Mol Biol Cell. 2014;25:2853-65 pubmed publisher
    ..In this model, SUN/KASH bridges serve as bolts through the nuclear envelope, and nucleoskeleton components LMN-1 and SAMP-1 act as both nuts and washers on the inside of the nucleus. ..
  3. Lawrence K, Tapley E, Cruz V, Li Q, Aung K, Hart K, et al. LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining. J Cell Biol. 2016;215:801-821 pubmed
    ..We propose that LINC complexes serve a conserved role in DNA repair through both the inhibition of NHEJ and the promotion of homologous recombination at sites of chromosomal breaks. ..