Gene Symbol: unc-83
Description: Nuclear migration protein unc-83;hypothetical protein
Alias: Nuclear migration protein unc-83;hypothetical protein
Species: Caenorhabditis elegans
Horvitz H, Sulston J. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics. 1980;96:435-54 pubmed
..Three of the mutants are suppressed by pleiotropic suppressors believed to be specific for null alleles, suggesting that their phenotypes result from the complete absence of gene activity. ..
McGee M, Rillo R, Anderson A, Starr D. UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84. Mol Biol Cell. 2006;17:1790-801 pubmed
..This mechanism seems conserved across eukaryotes and is the first proposed mechanism to target proteins specifically to the outer nuclear membrane. ..
Meyerzon M, Fridolfsson H, Ly N, McNally F, Starr D. UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration. Development. 2009;136:2725-33 pubmed publisher
Hedgecock E, Culotti J, Hall D, Stern B. Genetics of cell and axon migrations in Caenorhabditis elegans. Development. 1987;100:365-82 pubmed
..The first muscles and neurones may in turn express new surface molecules that refine later cell movements. Mutations in some 30 known genes disrupt the movements of cells or axons along the body wall. ..
Starr D, Hermann G, Malone C, Fixsen W, Priess J, Horvitz H, et al
. unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration. Development. 2001;128:5039-50 pubmed
..We favor a model in which UNC-84 directly recruits UNC-83 to the nuclear envelope where they help transfer force between the cytoskeleton and the nucleus...
Xu L, Wei Y, Reboul J, Vaglio P, Shin T, Vidal M, et al
. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature. 2003;425:316-21 pubmed
..elegans CUL-3. Biochemical studies using the BTB protein MEL-26 and its genetic target MEI-1 (refs 12, 13) indicate that BTB proteins merge the functional properties of Skp1 and F-box proteins into a single polypeptide. ..
Fridolfsson H, Ly N, Meyerzon M, Starr D. UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration. Dev Biol. 2010;338:237-50 pubmed publisher
..Kinesin-1 functions as the major force generator during nuclear migration, while dynein is involved in regulation of bidirectional transport of the nucleus. ..
Xiong H, Mohler W, Soto M. The branched actin nucleator Arp2/3 promotes nuclear migrations and cell polarity in the C. elegans zygote. Dev Biol. 2011;357:356-69 pubmed publisher
..In contrast with previous studies emphasizing pulling forces on the male pronucleus, we propose that robust MT nucleation pushes the male pronucleus anteriorly to join the female pronucleus...