Gene Symbol: unc-78
Description: Actin-interacting protein 1
Alias: Actin-interacting protein 1
Species: Caenorhabditis elegans
Mohri K, Ono S. Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform. J Cell Sci. 2003;116:4107-18 pubmed
..These results suggest that UNC-78 closely collaborates with UNC-60B to regulate actin dynamics in muscle cells. ..
Tischler J, Lehner B, Chen N, Fraser A. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol. 2006;7:R69 pubmed
Ono S. The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments. J Cell Biol. 2001;152:1313-9 pubmed
..Similar Unc-78 phenotypes are observed in both embryonic and adult muscles. Thus, AIP1 is an important regulator of actin filament organization and localization of ADF/cofilin during development of myofibrils. ..
Fares H, Greenwald I. Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Genetics. 2001;159:133-45 pubmed
Mohri K, Vorobiev S, Fedorov A, Almo S, Ono S. Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments. J Biol Chem. 2004;279:31697-707 pubmed
..These data support a model in which this conserved surface of AIP1 plays a direct role in enhancing fragmentation/depolymerization of ADF/cofilin-bound actin filaments but not in barbed end capping. ..
Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al
. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed
..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
Yamashiro S, Cox E, Baillie D, Hardin J, Ono S. Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans. J Cell Sci. 2008;121:3867-77 pubmed publisher
..Thus, we propose a model in which tropomodulin and enhancers of actin dynamics synergistically regulate elongation and shortening of actin filaments at the pointed end. ..
Yuan Y, Kadiyala C, Ching T, Hakimi P, Saha S, Xu H, et al
. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012;287:31414-26 pubmed publisher
..We conclude that an increase, not a decrease in fuel consumption, via an accelerated oxidation of fuels in the TCA cycle is involved in life span regulation; this mechanism may be conserved across phylogeny. ..
Fischer M, Regitz C, Kull R, Boll M, Wenzel U. Vitellogenins increase stress resistance of Caenorhabditis elegans after Photorhabdus luminescens infection depending on the steroid-signaling pathway. Microbes Infect. 2013;15:569-78 pubmed publisher
..Taken together, the study provides functional evidence for a crucial role of vitellogenins and the steroid-signaling pathway in determination of resistance against bacteria. ..