Gene Symbol: unc-68
Description: hypothetical protein
Species: Caenorhabditis elegans
Liu Q, Chen B, Yankova M, Morest D, Maryon E, Hand A, et al
. Presynaptic ryanodine receptors are required for normal quantal size at the Caenorhabditis elegans neuromuscular junction. J Neurosci. 2005;25:6745-54 pubmed
..These observations suggest that RYRs are essential to normal quantal size and are potential regulators of quantal size. ..
Cho J, Oh Y, Park K, Yu J, Choi K, Shin J, et al
. Calsequestrin, a calcium sequestering protein localized at the sarcoplasmic reticulum, is not essential for body-wall muscle function in Caenorhabditis elegans. J Cell Sci. 2000;113 ( Pt 22):3947-58 pubmed
..These findings suggest that although CSQ-1 is one of the major calcium-binding proteins in the body-wall muscles of C. elegans, it is not essential for body-wall muscle formation and contraction. ..
Syntichaki P, Samara C, Tavernarakis N. The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol. 2005;15:1249-54 pubmed
..Similar mechanisms may contribute to necrotic cell death that follows extreme acidosis-for example, during stroke-in humans. ..
Cho J, Ko K, Singaruvelu G, Lee W, Kang G, Rho S, et al
. Functional importance of polymerization and localization of calsequestrin in C. elegans. J Cell Sci. 2007;120:1551-8 pubmed
..In addition, direct interaction between CSQ-1 and the ryanodine receptor (RyR) was found for the first time, suggesting that the cellular localization of CSQ-1 in C. elegans is indeed modulated by RyR through a physical interaction. ..
Spooner P, Bonner J, Maricq A, Benian G, Norman K. Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans. PLoS ONE. 2012;7:e40182 pubmed publisher
..Thus, our data implicates UNC-89 in maintaining muscle cell architecture and that this precise organization is essential for optimal calcium mobilization and efficient and effective muscle contraction. ..
Lewis J, Wu C, Berg H, Levine J. The genetics of levamisole resistance in the nematode Caenorhabditis elegans. Genetics. 1980;95:905-28 pubmed
..elegans. And, as the most resistant class of mutants might lack pharmacologically functional acetyl-choline receptors (LEWIS et al. 1980), these mutants may also be of some neurobiological significance. ..
Hamada T, Sakube Y, Ahnn J, Kim D, Kagawa H. Molecular dissection, tissue localization and Ca2+ binding of the ryanodine receptor of Caenorhabditis elegans. J Mol Biol. 2002;324:123-35 pubmed
..We discuss the usefulness and limitations of the molecular dissection approach, which uses peptides and peptide-specific antibodies to determine the local structure and function of individual domains within a large molecule. ..