Gene Symbol: unc-64
Description: Syntaxin-1A homolog
Alias: Syntaxin-1A homolog
Species: Caenorhabditis elegans

Top Publications

  1. Saifee O, Wei L, Nonet M. The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin. Mol Biol Cell. 1998;9:1235-52 pubmed
  2. Madison J, Nurrish S, Kaplan J. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr Biol. 2005;15:2236-42 pubmed
    ..elegans and that, contrary to current models, the UNC-13/Syntaxin interaction is required for nerve-evoked vesicle fusion rather than synaptic-vesicle priming. Thus, UNC-13 may regulate multiple steps of the synaptic-vesicle cycle. ..
  3. Ogawa H, Harada S, Sassa T, Yamamoto H, Hosono R. Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin. J Biol Chem. 1998;273:2192-8 pubmed
    ..The binding of the mutant C. elegans syntaxin to UNC-18 is greatly reduced, indicating the mutation site contributes to the binding. ..
  4. Wu Q, Rui Q, He K, Shen L, Wang D. UNC-64 and RIC-4, the plasma membrane-associated SNAREs syntaxin and SNAP-25, regulate fat storage in nematode Caenorhabditis elegans. Neurosci Bull. 2010;26:104-16 pubmed publisher
    ..The plasma membrane-associated SNAREs syntaxin/unc-64 and SNAP-25/ric-4 function in parallel in regulating fat storage in C. elegans, probably through the ARC105/mdt-15- and SREBP/sbp-1-mediated signaling pathways. ..
  5. Hosono R, Kamiya Y. Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans. Neurosci Lett. 1991;128:243-4 pubmed
    ..These results suggest that the 7 genes are involved in some related functions. ..
  6. Nguyen M, Alfonso A, Johnson C, Rand J. Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase. Genetics. 1995;140:527-35 pubmed
    ..Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions...
  7. Ailion M, Inoue T, Weaver C, Holdcraft R, Thomas J. Neurosecretory control of aging in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1999;96:7394-7 pubmed
    ..We present evidence that the site of action of unc-64 is neuronal, suggesting that a neurosecretory signal regulates life span and dauer formation. ..
  8. Hammarlund M, Palfreyman M, Watanabe S, Olsen S, Jorgensen E. Open syntaxin docks synaptic vesicles. PLoS Biol. 2007;5:e198 pubmed
    ..These data provide a molecular basis for synaptic vesicle docking. ..
  9. Chua J, Butkevich E, Worseck J, Kittelmann M, Gr Nborg M, Behrmann E, et al. Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter. Proc Natl Acad Sci U S A. 2012;109:5862-7 pubmed publisher
    ..We conclude that FEZ1 operates as a kinesin adaptor for the transport of Stx, with cargo loading and unloading being regulated by protein kinases...

More Information


  1. Edwards M, Johnson J, Rankin K, Jenkins R, Maguire C, Morgan A, et al. PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion. J Neurosci. 2012;32:7042-51 pubmed publisher
    ..These data demonstrate that an individual DAG-dependent thermosensory behavior of an organism is effected specifically by the downstream PKC-2 phosphorylation of UNC-18 on Ser322 in AFD neurons. ..