Gene Symbol: unc-53
Description: Adapter protein unc-53;hypothetical protein
Alias: Adapter protein unc-53;hypothetical protein
Species: Caenorhabditis elegans
Products:     unc-53

Top Publications

  1. Stringham E, Pujol N, Vandekerckhove J, Bogaert T. unc-53 controls longitudinal migration in C. elegans. Development. 2002;129:3367-79 pubmed
    ..Thus, unc-53 is involved in longitudinal navigation and might act by linking extracellular guidance cues to the intracellular cytoskeleton. ..
  2. Trent C, Tsuing N, Horvitz H. Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics. 1983;104:619-47 pubmed
    ..At least two of the egl mutants appear to be defective in the processing of environmental signals that modulate egg laying and may define new components of the neural circuitry that control egg laying. ..
  3. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 1974;77:71-94 pubmed
    ..Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large. ..
  4. Chen E, Branda C, Stern M. Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites. Dev Biol. 1997;182:88-100 pubmed
    ..Mutations in let-60 ras and let-341 also confer sex myoblast migration defects in an unc-53 background, implicating these genes in gonad-dependent positioning as well. ..
  5. Fernandes J, Sternberg P. The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva. PLoS Genet. 2007;3:e69 pubmed
    ..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...
  6. Schmidt K, Marcus Gueret N, Adeleye A, Webber J, Baillie D, Stringham E. The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1. Development. 2009;136:563-74 pubmed publisher
    ..We propose that UNC-53/NAV2, through its CH domain, acts as a scaffold that links ABI-1 to the ARP2/3 complex to regulate actin cytoskeleton remodeling. ..
  7. McShea M, Schmidt K, Dubuke M, Baldiga C, Sullender M, Reis A, et al. Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans. Dev Biol. 2013;373:1-13 pubmed publisher
    ..Taken together, our results suggest that MIG-10, UNC-53, and ABI-1 act sequentially to mediate excretory cell process outgrowth...
  8. Katidou M, Tavernarakis N, Karagogeos D. The contactin RIG-6 mediates neuronal and non-neuronal cell migration in Caenorhabditis elegans. Dev Biol. 2013;373:184-95 pubmed publisher
    ..In addition, our data suggest that the cytoplasmic UNC-53/NAV2 proteins may contribute to relay signaling via contactins. ..
  9. Hodgkin J. Male Phenotypes and Mating Efficiency in CAENORHABDITIS ELEGANS. Genetics. 1983;103:43-64 pubmed
    ..Four of the mab (male abnormal) genes affect specific postembryonic cell lineages. ..

More Information


  1. Marzinke M, Mavencamp T, Duratinsky J, Clagett Dame M. 14-3-3? and NAV2 interact to regulate neurite outgrowth and axon elongation. Arch Biochem Biophys. 2013;540:94-100 pubmed publisher
    ..The discovery of an interaction between NAV2 and 14-3-3? could provide insight into the mechanism by which NAV2 participates in promoting cell migration and neuronal elongation...