unc 52


Gene Symbol: unc 52
Description: Basement membrane proteoglycan;hypothetical protein
Alias: Basement membrane proteoglycan;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Rogalski T, Gilchrist E, Mullen G, Moerman D. Mutations in the unc-52 gene responsible for body wall muscle defects in adult Caenorhabditis elegans are located in alternatively spliced exons. Genetics. 1995;139:159-69 pubmed
    ..This result suggests that reversion of the mutant phenotype in these strains may be the result of exon-skipping. ..
  2. Williams B, Waterston R. Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations. J Cell Biol. 1994;124:475-90 pubmed
    ..Similar evidence suggests that one of the genes associated with mild effects on lattice assembly may code for tropomyosin. Many of the newly identified genes are likely to play critical roles in muscle development and function. ..
  3. Rogalski T, Williams B, Mullen G, Moerman D. Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan. Genes Dev. 1993;7:1471-84 pubmed
    ..elegans fail to stain embryos homozygous for a lethal unc-52 allele. We have mapped the epitopes recognized by both monoclonal antibodies to a region of domain IV in the unc-52-encoded protein sequence. ..
  4. Raharjo W, Ghai V, Dineen A, Bastiani M, Gaudet J. Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx. Genetics. 2011;189:885-97 pubmed publisher
    ..We suggest that gland morphology is maintained by a balance of forces from the muscles and the glands...
  5. Lundquist E, Herman R. The mec-8 gene of Caenorhabditis elegans affects muscle and sensory neuron function and interacts with three other genes: unc-52, smu-1 and smu-2. Genetics. 1994;138:83-101 pubmed
    ..The suppressors, which define the genes smu-1 and smu-2, can weakly suppress all mec-8 mutant phenes. They also suppress the muscular dystrophy conferred by an unc-52(viable) mutation. ..
  6. Mullen G, Rogalski T, Bush J, Gorji P, Moerman D. Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans. Mol Biol Cell. 1999;10:3205-21 pubmed
    ..Neither short isoforms nor isoforms containing the C-terminal agrin-like region are essential for sarcomere assembly or muscle cell attachment, and their role in development remains unclear. ..
  7. Gilchrist E, Moerman D. Mutations in the sup-38 gene of Caenorhabditis elegans suppress muscle-attachment defects in unc-52 mutants. Genetics. 1992;132:431-42 pubmed
    ..Putative null sup-38 mutations cause maternal-effect lethality which is rescued by a wild-type copy of the locus in the zygote. These loss-of-function mutations have no effect on the body wall muscle structure. ..
  8. Muriel J, Xu X, Kramer J, Vogel B. Selective assembly of fibulin-1 splice variants reveals distinct extracellular matrix networks and novel functions for perlecan/UNC-52 splice variants. Dev Dyn. 2006;235:2632-40 pubmed
  9. Warner A, Xiong G, Qadota H, Rogalski T, Vogl A, Moerman D, et al. CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans. Mol Biol Cell. 2013;24:601-16 pubmed publisher
    ..We propose that CPNA-1 acts as a linker between an integrin-associated protein, PAT-6, and membrane-distal components of integrin adhesion complexes in the muscle of C. elegans. ..

More Information


  1. Etheridge T, Oczypok E, Lehmann S, Fields B, Shephard F, Jacobson L, et al. Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002471 pubmed publisher
    ..Since C. elegans lacks satellite cells, this mechanism is intrinsic to the muscles and raises the question if such a mechanism also exists in higher metazoans. ..
  2. Liang X, Dong X, Moerman D, Shen K, Wang X. Sarcomeres Pattern Proprioceptive Sensory Dendritic Endings through UNC-52/Perlecan in C. elegans. Dev Cell. 2015;33:388-400 pubmed publisher
    ..Hence, the muscular contractile apparatus provides the instructive cues to pattern proprioceptive dendrites. ..
  3. Zhang Y, Li W, Li L, Li Y, Fu R, Zhu Y, et al. Structural damage in the C. elegans epidermis causes release of STA-2 and induction of an innate immune response. Immunity. 2015;42:309-320 pubmed publisher
    ..Together, our findings uncover an evolutionarily conserved mechanism for the epithelial barriers to detect danger and activate immune defense. ..
  4. Jensen L, Møller T, Larsen S, Jakobsen H, Olsen A. A new role for laminins as modulators of protein toxicity in Caenorhabditis elegans. Aging Cell. 2012;11:82-92 pubmed publisher
    ..Laminins are evolutionarily conserved, and thus the BM may play a much more causal role in protein misfolding diseases than currently recognized. ..
  5. Ono K, Yu R, Ono S. Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation. Dev Dyn. 2007;236:1093-105 pubmed
    ..Our results provide basic information that helps understanding the mechanism of sheath contraction during ovulation and establishing a new model to study morphogenesis of nonstriated muscle. ..
  6. Merz D, Alves G, Kawano T, Zheng H, Culotti J. UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling. Dev Biol. 2003;256:173-86 pubmed
    ..We propose that UNC-52 serves dual roles in C. elegans larval development in the maintenance of muscle structure and the regulation of growth factor-like signaling pathways. ..
  7. Yuan Y, Kadiyala C, Ching T, Hakimi P, Saha S, Xu H, et al. Enhanced energy metabolism contributes to the extended life span of calorie-restricted Caenorhabditis elegans. J Biol Chem. 2012;287:31414-26 pubmed publisher
    ..We conclude that an increase, not a decrease in fuel consumption, via an accelerated oxidation of fuels in the TCA cycle is involved in life span regulation; this mechanism may be conserved across phylogeny. ..
  8. Zahreddine H, Zhang H, Diogon M, Nagamatsu Y, Labouesse M. CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development. Curr Biol. 2010;20:322-7 pubmed publisher
    ..Our findings should help understand how hemidesmosome dynamics are regulated in vertebrate systems. ..