Gene Symbol: unc-5
Description: Netrin receptor unc-5;hypothetical protein
Alias: Netrin receptor unc-5;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Colavita A, Culotti J. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol. 1998;194:72-85 pubmed
    ..Several of these mutations cause axon guidance defects similar to those found in unc-5 mutants. We propose that some or all of these genes may function in a developmentally important unc-5 signaling pathway. ..
  2. Norris A, Lundquist E. UNC-6/netrin and its receptors UNC-5 and UNC-40/DCC modulate growth cone protrusion in vivo in C. elegans. Development. 2011;138:4433-42 pubmed publisher
    ..g. filopodial) protrusion...
  3. MacNeil L, Hardy W, Pawson T, Wrana J, Culotti J. UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nat Neurosci. 2009;12:150-5 pubmed publisher
    ..Similar regulatory interactions between oppositely graded extracellular cues may be a common theme in guided cell and axon migrations. ..
  4. Poon V, Klassen M, Shen K. UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites. Nature. 2008;455:669-73 pubmed publisher
  5. Killeen M, Tong J, Krizus A, Steven R, Scott I, Pawson T, et al. UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. Dev Biol. 2002;251:348-66 pubmed
    ..Our data also show that part of the ZU-5 motif is required for UNC-40-independent signaling of UNC-5. ..
  6. Leung Hagesteijn C, Spence A, Stern B, Zhou Y, Su M, Hedgecock E, et al. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell. 1992;71:289-99 pubmed
    ..Mosaic analysis shows that unc-5 acts in migrating cells and pioneering neurons. We propose that UNC-5 is a transmembrane receptor expressed on the surface of motile cells and growth cones to guide dorsal movements. ..
  7. Kulkarni G, Li H, Wadsworth W. CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans. J Neurosci. 2008;28:4541-50 pubmed publisher
    ..We suggest CLEC-38 plays a role in promoting synapse assembly and refining axon outgrowth activity. ..
  8. Levy Strumpf N, Culotti J. Netrins and Wnts function redundantly to regulate antero-posterior and dorso-ventral guidance in C. elegans. PLoS Genet. 2014;10:e1004381 pubmed publisher
  9. Lee J, Li W, Guan K. SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans. Mol Cell Biol. 2005;25:6485-95 pubmed

More Information


  1. Ogura K, Goshima Y. The autophagy-related kinase UNC-51 and its binding partner UNC-14 regulate the subcellular localization of the Netrin receptor UNC-5 in Caenorhabditis elegans. Development. 2006;133:3441-50 pubmed
  2. Kruger R, Lee J, Li W, Guan K. Mapping netrin receptor binding reveals domains of Unc5 regulating its tyrosine phosphorylation. J Neurosci. 2004;24:10826-34 pubmed
    ..Moreover, experiments in Caenorhabditis elegans indicate that both netrin binding and nonbinding domains are necessary for phenotypic rescue of an unc-5 loss of function mutation. ..
  3. Schwabiuk M, Coudiere L, Merz D. SDN-1/syndecan regulates growth factor signaling in distal tip cell migrations in C. elegans. Dev Biol. 2009;334:235-42 pubmed publisher
    ..Together these results suggest that SDN-1 affects UNC-5 function by regulating the proper extracellular distribution of growth factors. ..
  4. Yee C, Sybingco S, Serdetchania V, Kholkina G, Bueno de Mesquita M, Naqvi Z, et al. ENU-3 is a novel motor axon outgrowth and guidance protein in C. elegans. Dev Biol. 2011;352:243-53 pubmed publisher
    ..We conclude that ENU-3 is a novel C. elegans protein that affects both motor axon outgrowth and guidance. ..
  5. Dalpé G, Tarsitano M, Persico M, Zheng H, Culotti J. C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum. Development. 2013;140:4020-30 pubmed publisher
    ..These data report the first case of VEGF-induced inhibition of the netrin signalling and a molecular conservation of VEGF function from worms to humans. ..
  6. Norris A, Sundararajan L, Morgan D, Roberts Z, Lundquist E. The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP. Development. 2014;141:4395-405 pubmed publisher
  7. Dixon S, Alexander M, Fernandes R, Ricker N, Roy P. FGF negatively regulates muscle membrane extension in Caenorhabditis elegans. Development. 2006;133:1263-75 pubmed
    ..Our data are consistent with a model in which integrins and laminins are needed for directed muscle arm extension to the nerve cords, while FGF signaling provides a general mechanism to regulate muscle membrane extension. ..
  8. Levy Strumpf N, Krizus M, Zheng H, Brown L, Culotti J. The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. PLoS Genet. 2015;11:e1005446 pubmed publisher