unc 49


Gene Symbol: unc 49
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 1974;77:71-94 pubmed
    ..Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large. ..
  2. McIntire S, Jorgensen E, Horvitz H. Genes required for GABA function in Caenorhabditis elegans. Nature. 1993;364:334-7 pubmed
    ..Some of these genes are likely to encode previously unidentified proteins required for GABA function. ..
  3. Bamber B, Beg A, Twyman R, Jorgensen E. The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor. J Neurosci. 1999;19:5348-59 pubmed
    ..Together these data argue that UNC-49B and UNC-49C coassemble at the C. elegans neuromuscular junction. Thus, C. elegans is able to encode a heteromeric GABA receptor with a single locus. ..
  4. Park M, Watanabe S, Poon V, Ou C, Jorgensen E, Shen K. CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron. 2011;70:742-57 pubmed publisher
  5. Tong X, Hu Z, Liu Y, Anderson D, Kaplan J. A network of autism linked genes stabilizes two pools of synaptic GABA(A) receptors. elife. 2015;4:e09648 pubmed publisher
    ..Our results suggest that these mutations may directly alter inhibitory transmission, which could contribute to the developmental and cognitive deficits observed in ASD. ..