Gene Symbol: unc-41
Description: Putative stoned B-like protein
Alias: Putative stoned B-like protein
Species: Caenorhabditis elegans

Top Publications

  1. Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
    ..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
  2. Jung N, Wienisch M, Gu M, Rand J, Müller S, Krause G, et al. Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. J Cell Biol. 2007;179:1497-510 pubmed publisher
    ..Synaptotagmin-binding-defective UNC-41B is unable to rescue paralysis in C. elegans stonin mutant animals, suggesting that the mechanism of stonin-mediated SV cargo recognition is conserved from worms to mammals. ..
  3. Ceol C, Horvitz H. A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Dev Cell. 2004;6:563-76 pubmed
    ..elegans development. ..
  4. Mullen G, Grundahl K, Gu M, Watanabe S, Hobson R, Crowell J, et al. UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans. PLoS ONE. 2012;7:e40095 pubmed publisher
    ..However, no further reduction in synaptic vesicles was observed in unc-41 apm-2 double mutants, suggesting that UNC-41 acts in the same endocytic pathway as µ2 adaptin. ..