Gene Symbol: unc 32
Description: Probable V-type proton ATPase 116 kDa subunit a
Alias: Probable V-type proton ATPase 116 kDa subunit a
Species: Caenorhabditis elegans
Pujol N, Bonnerot C, Ewbank J, Kohara Y, Thierry Mieg D. The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit. J Biol Chem. 2001;276:11913-21 pubmed
..Our results indicate that V-ATPase a subunit genes are highly regulated and have tissue-specific function. ..
Oka T, Toyomura T, Honjo K, Wada Y, Futai M. Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development. J Biol Chem. 2001;276:33079-85 pubmed
..These results suggest that V-ATPases with these isoforms generate acidic compartments essential for worm development in a cell-specific manner. ..
Syntichaki P, Samara C, Tavernarakis N. The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans. Curr Biol. 2005;15:1249-54 pubmed
..Similar mechanisms may contribute to necrotic cell death that follows extreme acidosis-for example, during stroke-in humans. ..
Nguyen M, Alfonso A, Johnson C, Rand J. Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase. Genetics. 1995;140:527-35 pubmed
..Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions...
Richardson C, Kooistra T, Kim D. An essential role for XBP-1 in host protection against immune activation in C. elegans. Nature. 2010;463:1092-5 pubmed publisher
..elegans development and indicate that an ancient, conserved role for XBP-1 may be to protect the host organism from the detrimental effects of mounting an innate immune response to microbes. ..
Irazoqui J, Troemel E, Feinbaum R, Luhachack L, Cezairliyan B, Ausubel F. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. PLoS Pathog. 2010;6:e1000982 pubmed publisher
..aeruginosa nor the S. aureus-triggered response requires canonical TLR signaling, they imply the existence of unidentified mechanisms for pathogen detection in C. elegans, with potentially conserved roles also in mammals. ..
Kuroyanagi H, Watanabe Y, Hagiwara M. CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans. PLoS Genet. 2013;9:e1003337 pubmed publisher
..Taken together, UNC-75 is the neuron-specific splicing factor and regulates both sets of the mutually exclusive exons of the unc-32 gene...