unc-29

Summary

Gene Symbol: unc-29
Description: Acetylcholine receptor subunit beta-type unc-29
Alias: Acetylcholine receptor subunit beta-type unc-29
Species: Caenorhabditis elegans

Top Publications

  1. Brenner S. The genetics of Caenorhabditis elegans. Genetics. 1974;77:71-94 pubmed
    ..Mutations in 77 of these alter the movement of the animal. Estimates of the induced mutation frequency of both the visible mutants and X chromosome lethals suggests that, just as in Drosophila, the genetic units in C. elegans are large. ..
  2. Fleming J, Squire M, Barnes T, Tornoe C, Matsuda K, Ahnn J, et al. Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. J Neurosci. 1997;17:5843-57 pubmed
    ..The identification of viable nAChR mutants in C. elegans provides an advantageous system in which receptor expression and synaptic targeting can be manipulated and studied in vivo. ..
  3. Richmond J, Jorgensen E. One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction. Nat Neurosci. 1999;2:791-7 pubmed
    ..By recording spontaneous endogenous currents and selectively eliminating each of these receptors, we demonstrated that all three receptor types function at neuromuscular synapses. ..
  4. Lewis J, Wu C, Berg H, Levine J. The genetics of levamisole resistance in the nematode Caenorhabditis elegans. Genetics. 1980;95:905-28 pubmed
    ..elegans. And, as the most resistant class of mutants might lack pharmacologically functional acetyl-choline receptors (LEWIS et al. 1980), these mutants may also be of some neurobiological significance. ..
  5. Jacob T, Kaplan J. The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions. J Neurosci. 2003;23:2122-30 pubmed
    ..Taken together, these results suggest that egl-21 CPE and egl-3 PC2 process endogenous neuropeptides that facilitate acetylcholine release at C. elegans NMJs. ..
  6. Keane J, Avery L. Mechanosensory inputs influence Caenorhabditis elegans pharyngeal activity via ivermectin sensitivity genes. Genetics. 2003;164:153-62 pubmed
  7. Gottschalk A, Schafer W. Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans. J Neurosci Methods. 2006;154:68-79 pubmed
    ..This showed that, theoretically, any molecular interaction of sufficient affinity may be used to specifically label cell surface structures in live nematodes. ..
  8. Yamashita M, Iwasaki K, Doi M. The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1. Biochem Biophys Res Commun. 2009;378:404-8 pubmed publisher
    ..These results suggest that a novel molecular interaction between the AEX-1 and syntaxin may regulate vesicle exocytosis for retrograde signal release. ..
  9. Rapti G, Richmond J, Bessereau J. A single immunoglobulin-domain protein required for clustering acetylcholine receptors in C. elegans. EMBO J. 2011;30:706-18 pubmed publisher
    ..These results add a novel paradigm for the immunoglobulin super-family as OIG-4 is a secreted protein required for clustering ionotropic receptors independently of synapse formation. ..

More Information

Publications11

  1. Kim J, Poole D, Waggoner L, Kempf A, Ramirez D, Treschow P, et al. Genes affecting the activity of nicotinic receptors involved in Caenorhabditis elegans egg-laying behavior. Genetics. 2001;157:1599-610 pubmed
  2. Jospin M, Qi Y, Stawicki T, Boulin T, Schuske K, Horvitz H, et al. A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biol. 2009;7:e1000265 pubmed publisher
    ..These data indicate that the ACR-2 receptor is important for the coordinated excitation and inhibition of body muscles underlying sinusoidal movement. ..