unc 25

Summary

Gene Symbol: unc 25
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Jin Y, Jorgensen E, Hartwieg E, Horvitz H. The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. J Neurosci. 1999;19:539-48 pubmed
    ..We conclude that GAD activity and GABA are not necessary for the development or maintenance of neuromuscular junctions in C. elegans. ..
  2. Locke C, Williams S, Schwarz E, Caldwell G, Caldwell K. Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 2006;1120:23-34 pubmed
    ..Thus, interactions among gene products with LIS-1 may mediate intrinsic thresholds of neuronal synchrony. ..
  3. Kawasaki M, Hisamoto N, Iino Y, Yamamoto M, Ninomiya Tsuji J, Matsumoto K. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. EMBO J. 1999;18:3604-15 pubmed
    ..Furthermore, ectopic expression of JKK-1 in type-D motor neurons is sufficient to rescue the movement defect. Thus, the C.elegans JNK pathway functions in type-D GABAergic motor neurons and thereby modulates coordinated locomotion. ..
  4. Sun Y, Hu Z, Goeb Y, Dreier L. The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans. PLoS ONE. 2013;8:e59132 pubmed publisher