Gene Symbol: unc-22
Description: Twitchin;hypothetical protein
Alias: Twitchin;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Kennedy S, Wang D, Ruvkun G. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature. 2004;427:645-9 pubmed
    ..Thus, ERI-1 is a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference. ..
  2. Tischler J, Lehner B, Chen N, Fraser A. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol. 2006;7:R69 pubmed
  3. Putzke A, Rothman J. Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci U S A. 2010;107:16154-9 pubmed publisher
    ..These findings highlight a role for a Fer-type kinase in setting the proper levels of Wnt signaling and demonstrate the importance of this modulation in ensuring appropriate cell division. ..
  4. Massirer K, Perez S, Mondol V, Pasquinelli A. The miR-35-41 family of microRNAs regulates RNAi sensitivity in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002536 pubmed publisher
    ..Our results reveal that miRNAs can broadly regulate other small RNA pathways and, thus, have far reaching effects on gene expression beyond directly targeting specific mRNAs. ..
  5. Moerman D, Benian G, Barstead R, Schriefer L, Waterston R. Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans. Genes Dev. 1988;2:93-105 pubmed
    ..In one case, a truncated polypeptide was also identified. The location of the protein in the A-band, along with earlier genetic data, suggests that the unc-22 product may interact with myosin to regulate its function...
  6. Heierhorst J, Tang X, Lei J, Probst W, Weiss K, Kemp B, et al. Substrate specificity and inhibitor sensitivity of Ca2+/S100-dependent twitchin kinases. Eur J Biochem. 1996;242:454-9 pubmed
    ..The twitchin kinase S100A1(2)-binding site can also bind Ca2+/calmodulin but neither kinase is activated by calmodulin. The data provide a functional basis for the ongoing crystallographic study of twitchin kinase fragments. ..
  7. Shibata Y, Branicky R, Landaverde I, Hekimi S. Redox regulation of germline and vulval development in Caenorhabditis elegans. Science. 2003;302:1779-82 pubmed
    ..The other pathway is the oncogenic ras signaling pathway, whose action on germline as well as vulval development appears to be modulated by cytoplasmic ROS. ..
  8. Hu Y, Xiao S, Aroian R. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009;3:e499 pubmed publisher
  9. Spooner P, Bonner J, Maricq A, Benian G, Norman K. Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans. PLoS ONE. 2012;7:e40182 pubmed publisher
    ..Thus, our data implicates UNC-89 in maintaining muscle cell architecture and that this precise organization is essential for optimal calcium mobilization and efficient and effective muscle contraction. ..

More Information


  1. Johnson N, Behm C, Trowell S. Heritable and inducible gene knockdown in C. elegans using Wormgate and the ORFeome. Gene. 2005;359:26-34 pubmed
    ..Further, when combined with the rrf-3 RNAi hypersensitive strain, the Wormgate approach delivered a highly penetrant knockdown phenotype in nearly 100% of worms for a gene that was completely refractory to other RNAi delivery methods. ..
  2. Matsunaga Y, Qadota H, Furukawa M, Choe H, Benian G. Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle. Mol Biol Cell. 2015;26:2096-111 pubmed publisher
    ..These results suggest that MAK-1 is an activator of twitchin kinase and that the p38 MAP kinase pathway may be involved in the regulation of twitchin. ..