unc-13

Summary

Gene Symbol: unc-13
Description: Phorbol ester/diacylglycerol-binding protein unc-13;hypothetical protein
Alias: Phorbol ester/diacylglycerol-binding protein unc-13;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Kohn R, Duerr J, McManus J, Duke A, Rakow T, Maruyama H, et al. Expression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system. Mol Biol Cell. 2000;11:3441-52 pubmed
    ..This finding suggests some degree of functional overlap of the different protein products. ..
  2. Madison J, Nurrish S, Kaplan J. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr Biol. 2005;15:2236-42 pubmed
    ..elegans and that, contrary to current models, the UNC-13/Syntaxin interaction is required for nerve-evoked vesicle fusion rather than synaptic-vesicle priming. Thus, UNC-13 may regulate multiple steps of the synaptic-vesicle cycle. ..
  3. Deken S, Vincent R, Hadwiger G, Liu Q, Wang Z, Nonet M. Redundant localization mechanisms of RIM and ELKS in Caenorhabditis elegans. J Neurosci. 2005;25:5975-83 pubmed
    ..Furthermore, they demonstrate that multiple different protein-protein interactions redundantly anchor both ELKS and RIM to active zones and implicate novel proteins in the formation of the active zone. ..
  4. Richmond J, Davis W, Jorgensen E. UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat Neurosci. 1999;2:959-64 pubmed
    ..These experiments support models in which UNC-13 mediates either fusion of vesicles during exocytosis or priming of vesicles for fusion. ..
  5. Hammarlund M, Palfreyman M, Watanabe S, Olsen S, Jorgensen E. Open syntaxin docks synaptic vesicles. PLoS Biol. 2007;5:e198 pubmed
    ..These data provide a molecular basis for synaptic vesicle docking. ..
  6. Hu Z, Tong X, Kaplan J. UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans. elife. 2013;2:e00967 pubmed publisher
    ..These results suggest that UNC-13L, UNC-13S, and Tomosyn form a molecular code that dictates the timing of neurotransmitter release. DOI:http://dx.doi.org/10.7554/eLife.00967.001. ..
  7. McEwen J, Madison J, Dybbs M, Kaplan J. Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13. Neuron. 2006;51:303-15 pubmed
    ..Even when priming was restored, synaptic transmission remained defective in unc-13 mutants, suggesting that UNC-13 is also required for other aspects of secretion. ..
  8. Chapin A, Correa P, Maguire M, Kohn R. Synaptic neurotransmission protein UNC-13 affects RNA interference in neurons. Biochem Biophys Res Commun. 2007;354:1040-4 pubmed
    ..There is no evidence for altered neurotransmission in eri-1 mutants. ..
  9. de Carvalho C, Zaaijer S, Smolikov S, Gu Y, Schumacher J, COLAIACOVO M. LAB-1 antagonizes the Aurora B kinase in C. elegans. Genes Dev. 2008;22:2869-85 pubmed publisher
    ..We propose that, in C. elegans, a LAB-1-mediated mechanism evolved to offset the challenges of providing protection against separase activity throughout a larger chromosome area. ..

More Information

Publications17

  1. Bastiani C, Gharib S, Simon M, Sternberg P. Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle. Genetics. 2003;165:1805-22 pubmed
    ..Our data indicate that there are multiple signaling pathways downstream of EGL-30 and that different pathways could predominate with respect to the regulation of different behaviors. ..
  2. Zhou K, Stawicki T, Goncharov A, Jin Y. Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics. elife. 2013;2:e01180 pubmed publisher
    ..These data reveal multiple roles of UNC-13 C2A domain, and suggest that spontaneous release and the fast phase of evoked release may involve a common pool of SVs at the active zone. DOI: http://dx.doi.org/10.7554/eLife.01180.001. ..
  3. Spike C, Coetzee D, Nishi Y, Guven Ozkan T, Oldenbroek M, Yamamoto I, et al. Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans. Genetics. 2014;198:1513-33 pubmed publisher
    ..Taken together, these data support a model in which the conserved regulators of mRNA translation LIN-41 and OMA-1/2 coordinately control oocyte growth and the proper spatial and temporal execution of the meiotic maturation decision. ..
  4. Lipstein N, Verhoeven Duif N, Michelassi F, Calloway N, van Hasselt P, PieĊ„kowska K, et al. Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder. J Clin Invest. 2017;127:1005-1018 pubmed publisher
    ..Further, it adds the neuronal Munc13 proteins and the synaptic vesicle priming process that they control to the known etiological mechanisms of psychiatric and neurological synaptopathies. ..
  5. Speese S, Petrie M, Schuske K, Ailion M, Ann K, Iwasaki K, et al. UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans. J Neurosci. 2007;27:6150-62 pubmed
    ..Our results suggest that CAPS/UNC-31 and UNC-13 serve parallel and dedicated roles in dense-core vesicle and synaptic vesicle exocytosis, respectively, in the C. elegans nervous system. ..
  6. He K, Shen L, Zhou W, Wang D. Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent. Neurosci Bull. 2009;25:335-42 pubmed publisher
    ..The regulation of aging by unc-13 and sbt-1 is temperature-dependent. And the alterations in reproduction capability and stress response may be associated with the formation of this temperature-dependent property. ..
  7. Michelassi F, Liu H, Hu Z, Dittman J. A C1-C2 Module in Munc13 Inhibits Calcium-Dependent Neurotransmitter Release. Neuron. 2017;95:577-590.e5 pubmed publisher
    ..Thus, C1-C2B exerts a basal inhibition on Munc13 in the primed state, permitting calcium- and lipid-dependent control of C1-C2B to modulate synaptic strength. ..
  8. Park S, Bin N, Yu B, Wong R, Sitarska E, Sugita K, et al. UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans. J Neurosci. 2017;37:8797-8815 pubmed publisher
    ..Thus, our study provides novel mechanistic insights into how Munc18/UNC-18 primes synaptic vesicle release and how this protein interacts functionally with Munc13/UNC-13 and Tomosyn/TOM-1. ..