Gene Symbol: unc-129
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Colavita A, Culotti J. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol. 1998;194:72-85 pubmed
    ..Several of these mutations cause axon guidance defects similar to those found in unc-5 mutants. We propose that some or all of these genes may function in a developmentally important unc-5 signaling pathway. ..
  2. Colavita A, Krishna S, Zheng H, Padgett R, Culotti J. Pioneer axon guidance by UNC-129, a C. elegans TGF-beta. Science. 1998;281:706-9 pubmed
    ..Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans. ..
  3. Ikegami R, Zheng H, Ong S, Culotti J. Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans. Dev Cell. 2004;6:383-95 pubmed
    ..We present a model for the integrated control of TGF-beta, semaphorin, and ephrin signaling in the sorting of cell clusters into distinct rays in the developing male tail. ..
  4. MacNeil L, Hardy W, Pawson T, Wrana J, Culotti J. UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nat Neurosci. 2009;12:150-5 pubmed publisher
    ..Similar regulatory interactions between oppositely graded extracellular cues may be a common theme in guided cell and axon migrations. ..
  5. Poon V, Klassen M, Shen K. UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites. Nature. 2008;455:669-73 pubmed publisher
  6. Kersey R, Brodigan T, Fukushige T, Krause M. Regulation of UNC-130/FOXD-mediated mesodermal patterning in C. elegans. Dev Biol. 2016;416:300-11 pubmed publisher
    ..These results further our understanding of the transcriptional logic behind the generation of polarity cues involving this poorly understood subclass of Forkhead factors. ..