Gene Symbol: unc-129
Description: hypothetical protein
Species: Caenorhabditis elegans
Colavita A, Culotti J. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev Biol. 1998;194:72-85 pubmed
..Several of these mutations cause axon guidance defects similar to those found in unc-5 mutants. We propose that some or all of these genes may function in a developmentally important unc-5 signaling pathway. ..
Colavita A, Krishna S, Zheng H, Padgett R, Culotti J. Pioneer axon guidance by UNC-129, a C. elegans TGF-beta. Science. 1998;281:706-9 pubmed
..Thus, UNC-129 mediates expression of dorsoventral polarity information required for axon guidance and guided cell migrations in C. elegans. ..
Ikegami R, Zheng H, Ong S, Culotti J. Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans. Dev Cell. 2004;6:383-95 pubmed
..We present a model for the integrated control of TGF-beta, semaphorin, and ephrin signaling in the sorting of cell clusters into distinct rays in the developing male tail. ..
MacNeil L, Hardy W, Pawson T, Wrana J, Culotti J. UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways. Nat Neurosci. 2009;12:150-5 pubmed publisher
..Similar regulatory interactions between oppositely graded extracellular cues may be a common theme in guided cell and axon migrations. ..
Poon V, Klassen M, Shen K. UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites. Nature. 2008;455:669-73 pubmed publisher
Kersey R, Brodigan T, Fukushige T, Krause M. Regulation of UNC-130/FOXD-mediated mesodermal patterning in C. elegans. Dev Biol. 2016;416:300-11 pubmed publisher
..These results further our understanding of the transcriptional logic behind the generation of polarity cues involving this poorly understood subclass of Forkhead factors. ..