unc 119


Gene Symbol: unc 119
Description: Protein unc-119;hypothetical protein
Alias: Protein unc-119;hypothetical protein
Species: Caenorhabditis elegans
Products:     unc 119

Top Publications

  1. Maduro M, Pilgrim D. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics. 1995;141:977-88 pubmed
    ..Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system. ..
  2. Ou G, Koga M, Blacque O, Murayama T, Ohshima Y, Schafer J, et al. Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell. 2007;18:1554-69 pubmed
  3. Materi W, Pilgrim D. Novel Caenorhabditis elegans unc-119 axon outgrowth defects correlate with behavioral phenotypes that are partially rescued by nonneural unc-119. Genesis. 2005;42:104-16 pubmed
  4. Su C, Tharin S, Jin Y, Wightman B, Spector M, Meili D, et al. The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans. J Biol. 2006;5:9 pubmed publisher
    ..elegans. As both proteins are conserved through evolution, we suggest that the mammalian homologs of UNC-69 and UNC-76 (SCOCO and FEZ, respectively) may function similarly. ..
  5. Zhang Q, Li Y, Zhang Y, Torres V, Harris P, Ling K, et al. GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119. Sci Rep. 2016;6:24534 pubmed publisher
  6. Knobel K, Davis W, Jorgensen E, Bastiani M. UNC-119 suppresses axon branching in C. elegans. Development. 2001;128:4079-92 pubmed
    ..Finally, UNC-119 is located in neuron cell bodies and axons and acts cell-autonomously to inhibit axon branching. ..
  7. Mörck C, Axäng C, Pilon M. A genetic analysis of axon guidance in the C elegans pharynx. Dev Biol. 2003;260:158-75 pubmed
    ..We isolated five novel mutants in a screen for worms exhibiting abnormal morphology of the M2 neurons. These mutants define a new gene class designated mnm (M neuron morphology abnormal). ..
  8. Alpadi K, Magupalli V, Käppel S, Köblitz L, Schwarz K, Seigel G, et al. RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses. J Biol Chem. 2008;283:26461-7 pubmed publisher
    ..We show that Munc119 can be recruited to synaptic ribbons via its interaction with RIBEYE. Our data suggest that the RIBEYE-Munc119 interaction is essential for synaptic transmission at the photoreceptor ribbon synapse. ..
  9. Wright K, Baye L, Olivier Mason A, Mukhopadhyay S, Sang L, Kwong M, et al. An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes Dev. 2011;25:2347-60 pubmed publisher
    ..Our results uncover a selective, membrane targeting GTPase cycle that delivers myristoylated proteins to the ciliary membrane and suggest that other myristoylated proteins may be similarly targeted to specialized membrane domains. ..

More Information


  1. Knutson A, Egelhofer T, Rechtsteiner A, Strome S. Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline. Genetics. 2017;206:163-178 pubmed publisher
    ..Our data identify P granules as critical modulators of the germline transcriptome and guardians of germ cell fate. ..