Gene Symbol: unc 119
Description: Protein unc-119;hypothetical protein
Alias: Protein unc-119;hypothetical protein
Species: Caenorhabditis elegans
Maduro M, Pilgrim D. Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics. 1995;141:977-88 pubmed
..Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system. ..
Ou G, Koga M, Blacque O, Murayama T, Ohshima Y, Schafer J, et al
. Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell. 2007;18:1554-69 pubmed
Materi W, Pilgrim D. Novel Caenorhabditis elegans unc-119 axon outgrowth defects correlate with behavioral phenotypes that are partially rescued by nonneural unc-119. Genesis. 2005;42:104-16 pubmed
Su C, Tharin S, Jin Y, Wightman B, Spector M, Meili D, et al
. The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans. J Biol. 2006;5:9 pubmed publisher
..elegans. As both proteins are conserved through evolution, we suggest that the mammalian homologs of UNC-69 and UNC-76 (SCOCO and FEZ, respectively) may function similarly. ..
Zhang Q, Li Y, Zhang Y, Torres V, Harris P, Ling K, et al
. GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119. Sci Rep. 2016;6:24534 pubmed publisher
Knobel K, Davis W, Jorgensen E, Bastiani M. UNC-119 suppresses axon branching in C. elegans. Development. 2001;128:4079-92 pubmed
..Finally, UNC-119 is located in neuron cell bodies and axons and acts cell-autonomously to inhibit axon branching. ..
Mörck C, Axäng C, Pilon M. A genetic analysis of axon guidance in the C elegans pharynx. Dev Biol. 2003;260:158-75 pubmed
..We isolated five novel mutants in a screen for worms exhibiting abnormal morphology of the M2 neurons. These mutants define a new gene class designated mnm (M neuron morphology abnormal). ..
Alpadi K, Magupalli V, Käppel S, Köblitz L, Schwarz K, Seigel G, et al
. RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses. J Biol Chem. 2008;283:26461-7 pubmed publisher
..We show that Munc119 can be recruited to synaptic ribbons via its interaction with RIBEYE. Our data suggest that the RIBEYE-Munc119 interaction is essential for synaptic transmission at the photoreceptor ribbon synapse. ..
Wright K, Baye L, Olivier Mason A, Mukhopadhyay S, Sang L, Kwong M, et al
. An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes Dev. 2011;25:2347-60 pubmed publisher
..Our results uncover a selective, membrane targeting GTPase cycle that delivers myristoylated proteins to the ciliary membrane and suggest that other myristoylated proteins may be similarly targeted to specialized membrane domains. ..