Genomes and Genes
Gene Symbol: unc-116
Description: Kinesin heavy chain
Alias: Kinesin heavy chain
Species: Caenorhabditis elegans
- Sakamoto R, Byrd D, Brown H, Hisamoto N, Matsumoto K, Jin Y. The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Mol Biol Cell. 2005;16:483-96 pubmedKinesin-1 is a heterotetramer composed of kinesin heavy chain (KHC) and kinesin light chain (KLC). The Caenorhabditis elegans genome has a single KHC, encoded by the unc-116 gene, and two KLCs, encoded by the klc-1 and klc-2 genes...
- Berends C, Munoz J, Portegijs V, Schmidt R, Grigoriev I, Boxem M, et al. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Mol Biol Cell. 2013;24:2201-15 pubmed publisher..These results emphasize the contribution of membrane-associated and cortical proteins other than G?-GPR-LIN-5 in balancing the pulling forces that position the spindle during asymmetric cell division. ..
- Hoerndli F, Maxfield D, Brockie P, Mellem J, Jensen E, Wang R, et al. Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors. Neuron. 2013;80:1421-37 pubmed publisher..Our data support a model in which ongoing motor-driven delivery and removal of AMPARs controls not only the number but also the composition of synaptic AMPARs, and thus the strength of synaptic transmission...