Gene Symbol: unc-116
Description: Kinesin heavy chain
Alias: Kinesin heavy chain
Species: Caenorhabditis elegans

Top Publications

  1. Yang H, Mains P, McNally F. Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. J Cell Biol. 2005;169:447-57 pubmed
    ..This study thus reveals two sequential mechanisms for translocating anastral spindles to the oocyte cortex. ..
  2. Aguirre Chen C, Bülow H, Kaprielian Z. C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites. Development. 2011;138:507-18 pubmed publisher
  3. Troulinaki K, Tavernarakis N. Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J. 2012;31:654-66 pubmed publisher
    ..These findings demonstrate a prominent role for endocytosis in cellular destruction during neurodegeneration, which is likely conserved in metazoans. ..
  4. Han X, Gomes J, Birmingham C, Pintard L, Sugimoto A, Mains P. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Genetics. 2009;181:933-43 pubmed publisher
    ..The redundant regulatory pathways likely contribute in different ways to the rapid and precise post-meiotic inactivation of MEI-1 microtubule-severing activity. ..
  5. Meyerzon M, Fridolfsson H, Ly N, McNally F, Starr D. UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration. Development. 2009;136:2725-33 pubmed publisher
  6. Tien N, Wu G, Hsu C, Chang C, Wagner O. Tau/PTL-1 associates with kinesin-3 KIF1A/UNC-104 and affects the motor's motility characteristics in C. elegans neurons. Neurobiol Dis. 2011;43:495-506 pubmed publisher
  7. Teulière J, Gally C, Garriga G, Labouesse M, Georges Labouesse E. MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1. Development. 2011;138:4475-85 pubmed publisher
    ..Together, these results support a model in which the MIG-15 kinase and the UNC-116-WVE-1 complex act on opposite sides of the growth cone to promote robust directional migration. ..
  8. Yan J, Chao D, Toba S, Koyasako K, Yasunaga T, Hirotsune S, et al. Kinesin-1 regulates dendrite microtubule polarity in Caenorhabditis elegans. elife. 2013;2:e00133 pubmed publisher
    ..In unc-116 (kinesin-1/kinesin heavy chain) mutants, the dendritic MTs adopt an axonal-like plus-end-out organization...
  9. Taylor C, Yan J, Howell A, Dong X, Shen K. RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport. PLoS Genet. 2015;11:e1005695 pubmed publisher

More Information


  1. Sakamoto R, Byrd D, Brown H, Hisamoto N, Matsumoto K, Jin Y. The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization. Mol Biol Cell. 2005;16:483-96 pubmed
    Kinesin-1 is a heterotetramer composed of kinesin heavy chain (KHC) and kinesin light chain (KLC). The Caenorhabditis elegans genome has a single KHC, encoded by the unc-116 gene, and two KLCs, encoded by the klc-1 and klc-2 genes...
  2. Berends C, Munoz J, Portegijs V, Schmidt R, Grigoriev I, Boxem M, et al. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Mol Biol Cell. 2013;24:2201-15 pubmed publisher
    ..These results emphasize the contribution of membrane-associated and cortical proteins other than G?-GPR-LIN-5 in balancing the pulling forces that position the spindle during asymmetric cell division. ..
  3. Hoerndli F, Maxfield D, Brockie P, Mellem J, Jensen E, Wang R, et al. Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors. Neuron. 2013;80:1421-37 pubmed publisher
    ..Our data support a model in which ongoing motor-driven delivery and removal of AMPARs controls not only the number but also the composition of synaptic AMPARs, and thus the strength of synaptic transmission...