Gene Symbol: unc 101
Description: AP-1 complex subunit mu-1-I;hypothetical protein
Alias: AP-1 complex subunit mu-1-I;hypothetical protein
Species: Caenorhabditis elegans
Lee J, Jongeward G, Sternberg P. unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein. Genes Dev. 1994;8:60-73 pubmed
..We have sequenced the mutant alleles of unc-101 identified in various genetic screens and shown that all but one are deletions or nonsense mutations, suggesting that these alleles severely reduce unc-101 function...
Skorobogata O, Escobar Restrepo J, Rocheleau C. An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. PLoS Genet. 2014;10:e1004728 pubmed publisher
..Thus, an AGEF-1/Arf GTPase/AP-1 ensemble functions opposite the LIN-2/7/10 complex to antagonize LET-23 EGFR basolateral membrane localization and signaling. ..
Zhou X, Zeng J, Ouyang C, Luo Q, Yu M, Yang Z, et al
. A novel bipartite UNC-101/AP-1 Î¼1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans. FEBS Lett. 2016;590:76-92 pubmed publisher
..Furthermore, we found that AP-1 interacts with the bipartite signal through UNC-101/AP-1 Î¼ N-terminal predicted Longin-like domain. Our results provide new insight into the mechanisms of Kv2.1 post-Golgi sorting and targeting. ..
Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
Ou G, Koga M, Blacque O, Murayama T, Ohshima Y, Schafer J, et al
. Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell. 2007;18:1554-69 pubmed
Holmes A, Flett A, Coudreuse D, Korswagen H, Pettitt J. C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex. J Cell Sci. 2007;120:2741-51 pubmed
Brear A, Yoon J, Wojtyniak M, Sengupta P. Diverse cell type-specific mechanisms localize G protein-coupled receptors to Caenorhabditis elegans sensory cilia. Genetics. 2014;197:667-84 pubmed publisher
Gillard G, Shafaq Zadah M, Nicolle O, Damaj R, PÃ©crÃ©aux J, Michaux G. Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in C. elegans epidermal cells. Development. 2015;142:1684-94 pubmed publisher
..We therefore propose that a molecular pathway, containing SOAP-1, AP-1 and clathrin, controls the apical delivery of E-cad and morphogenesis. ..