Genomes and Genes

Species

Gene Symbol: ulp-2

Description: Ubiquitin-Like Protease;Ubiquitin-like protease 2

Alias: Ubiquitin-Like Protease;Ubiquitin-like protease 2

Species: Caenorhabditis elegans

Pelisch F, Sonneville R, Pourkarimi E, Agostinho A, Blow J, Gartner A, et al. Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nat Commun. 2014;5:5485 pubmed publisher

..Moreover, ULP-4 is necessary for Aurora B(AIR-2) extraction from chromatin and relocation to the spindle mid-zone. Our results show that dynamic SUMO conjugation plays a role in cell cycle progression. ..
Tsur A, Bening Abu Shach U, Broday L. ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions. Dev Cell. 2015;35:63-77 pubmed publisher

..Our study provides a mechanistic link between the dynamic nature of the SUMO machinery and AJ plasticity and highlight sumoylation as a molecular switch that modulates the binding of E-cadherin to the actin cytoskeleton. ..