Gene Symbol: ufd-1
Description: Ubiquitin Fusion Degradation (yeast UFD homolog);Ubiquitin fusion degradation protein 1 homolog
Alias: Ubiquitin Fusion Degradation (yeast UFD homolog);Ubiquitin fusion degradation protein 1 homolog
Species: Caenorhabditis elegans
Poteryaev D, Squirrell J, Campbell J, White J, Spang A. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Mol Biol Cell. 2005;16:2139-53 pubmed
..Both proteins have been implicated in homotypic ER membrane fusion. We provide evidence that homotypic membrane fusion is required to form the sheet structure in the early embryo. ..
Mouysset J, Kähler C, Hoppe T. A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation. J Struct Biol. 2006;156:41-9 pubmed
..Together, these data suggest an evolutionarily conserved retro-translocation machinery at the endoplasmic reticulum. ..
Gomez Eyles J, Svendsen C, Lister L, Martin H, Hodson M, Spurgeon D. Measuring and modelling mixture toxicity of imidacloprid and thiacloprid on Caenorhabditis elegans and Eisenia fetida. Ecotoxicol Environ Saf. 2009;72:71-9 pubmed publisher
..For improving ecological risk assessment of simple mixtures, this implies that the concentration addition model may need to be used in a probabilistic context, rather than in its traditional deterministic manner. ..
Mouysset J, Deichsel A, Moser S, Hoege C, Hyman A, Gartner A, et al
. Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc Natl Acad Sci U S A. 2008;105:12879-84 pubmed publisher
..Our findings identified a role for CDC-48(UFD-1/NPL-4) in DNA replication, which is important for cell cycle progression and genome stability. ..
Sasagawa Y, Yamanaka K, Saito Sasagawa Y, Ogura T. Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis. Genes Cells. 2010;15:1201-15 pubmed publisher
..Taken together, these results suggest that UBXN-1, UBXN-2 and UBXN-3 are redundant cofactors for CDC-48/p97 and control spermatogenesis via the degradation of TRA-1A. ..
Sasagawa Y, Yamanaka K, Ogura T. ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans. Genes Cells. 2007;12:1063-73 pubmed
..We propose that E3 ubiquitin ligases function in concert with a specific partner chaperone. ..
Heallen T, Adams H, Furuta T, Verbrugghe K, Schumacher J. An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2. Dev Cell. 2008;15:603-16 pubmed publisher