Gene Symbol: tlk-1
Description: Serine/threonine-protein kinase tousled-like 1;Tousled-Like Kinase
Alias: Serine/threonine-protein kinase tousled-like 1;Tousled-Like Kinase
Species: Caenorhabditis elegans

Top Publications

  1. Han Z, Saam J, Adams H, Mango S, Schumacher J. The C. elegans Tousled-like kinase (TLK-1) has an essential role in transcription. Curr Biol. 2003;13:1921-9 pubmed
    ..In addition, our results confirm that the link between RNAPII phosphorylation and histone H3 methylation previously observed in budding yeast is functionally conserved in metazoans. ..
  2. Han Z, Riefler G, Saam J, Mango S, Schumacher J. The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase. Curr Biol. 2005;15:894-904 pubmed
  3. Yeh C, Yang H, Lee I, Wu Y. Caenorhabditis elegans TLK-1 controls cytokinesis by localizing AIR-2/Aurora B to midzone microtubules. Biochem Biophys Res Commun. 2010;400:187-93 pubmed publisher
    ..Interestingly, human TLK2 could functionally substitute for tlk-1, suggesting that the mitotic roles of TLK members might be evolutionarily conserved. ..
  4. Bender L, Suh J, Carroll C, Fong Y, Fingerman I, Briggs S, et al. MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Development. 2006;133:3907-17 pubmed
    ..We discuss how an autosomally associated HMT may participate in silencing genes on the X chromosome, in coordination with the direct silencing effects of the other MES proteins. ..
  5. Riefler G, Dent S, Schumacher J. Tousled-mediated activation of Aurora B kinase does not require Tousled kinase activity in vivo. J Biol Chem. 2008;283:12763-8 pubmed publisher
    ..Together, these results provide critical and compelling evidence that Tousled has a bona fide kinase-independent role in the activation of Aurora B kinases in vivo. ..