Gene Symbol: tbg-1
Description: Tubulin gamma chain
Alias: Tubulin gamma chain
Species: Caenorhabditis elegans
Products:     tbg-1

Top Publications

  1. Strome S, Powers J, Dunn M, Reese K, Malone C, White J, et al. Spindle dynamics and the role of gamma-tubulin in early Caenorhabditis elegans embryos. Mol Biol Cell. 2001;12:1751-64 pubmed
    ..Our results suggest that gamma-tubulin is not absolutely required for microtubule nucleation in C. elegans but is required for the normal organization and function of kinetochore and interpolar microtubules. ..
  2. Hannak E, Oegema K, Kirkham M, GONCZY P, Habermann B, Hyman A. The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent. J Cell Biol. 2002;157:591-602 pubmed
    ..Thus, although unknown mechanisms can support partial assembly of mitotic centrosomal asters, gamma-tubulin is the kinetically dominant centrosomal MT nucleator. ..
  3. Tabish M. Expression of gamma-tubulin during the development of nematode Caenorhabditis elegans. Mol Biol Rep. 2007;34:233-40 pubmed
    ..Using tbg-1::lacZ fusion gene expression studies in the germ line transformed worms, it was further revealed that gamma-tubulin expression was observed through out the development from embryonic and post-embryonic stages. ..
  4. Wang S, Wu D, Quintin S, Green R, Cheerambathur D, Ochoa S, et al. NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans. elife. 2015;4:e08649 pubmed publisher
    ..These results show that NOCA-1 acts with γ-tubulin to assemble non-centrosomal arrays in multiple tissues and highlight functional overlap between the ninein and Patronin protein families. ..
  5. Stubenvoll M, Medley J, Irwin M, Song M. ATX-2, the C. elegans Ortholog of Human Ataxin-2, Regulates Centrosome Size and Microtubule Dynamics. PLoS Genet. 2016;12:e1006370 pubmed publisher
    ..Our data suggest that RNA-binding proteins play an active role in controlling MT dynamics and provide insight into the control of proper centrosome size and MT dynamics. ..
  6. Bobinnec Y, Fukuda M, Nishida E. Identification and characterization of Caenorhabditis elegans gamma-tubulin in dividing cells and differentiated tissues. J Cell Sci. 2000;113 Pt 21:3747-59 pubmed
    ..In addition, we demonstrate the prominent redistribution of gamma-tubulin in adults at basal bodies of amphid and phasmid neurons, and at the apical membrane of polarized intestinal cells. ..
  7. Srayko M, Kaya A, Stamford J, Hyman A. Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo. Dev Cell. 2005;9:223-36 pubmed
    ..However, we found that centrosomes do not nucleate MTs to saturation; rather, the depolymerizing kinesin-13 subfamily member KLP-7 is required to limit microtubule outgrowth from centrosomes. ..
  8. Dammermann A, Maddox P, Desai A, Oegema K. SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. J Cell Biol. 2008;180:771-85 pubmed publisher
    ..Such a mechanism may help restrict new centriole assembly to the vicinity of preexisting parent centrioles that recruit PCM...
  9. Han X, Gomes J, Birmingham C, Pintard L, Sugimoto A, Mains P. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Genetics. 2009;181:933-43 pubmed publisher
    ..The redundant regulatory pathways likely contribute in different ways to the rapid and precise post-meiotic inactivation of MEI-1 microtubule-severing activity. ..