Gene Symbol: tbc-8
Description: TBC (Tre-2/Bub2/Cdc16) domain family
Alias: TBC (Tre-2/Bub2/Cdc16) domain family
Species: Caenorhabditis elegans

Top Publications

  1. Hannemann M, Sasidharan N, Hegermann J, Kutscher L, Koenig S, Eimer S. TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002722 pubmed publisher
    ..Therefore, we propose that a dynamic ON/OFF cycling of RAB-2 at the Golgi induced by the GAP/effector complex is required for proper DCV maturation. ..
  2. Ailion M, Hannemann M, Dalton S, Pappas A, Watanabe S, Hegermann J, et al. Two Rab2 interactors regulate dense-core vesicle maturation. Neuron. 2014;82:167-80 pubmed publisher
    ..RUND-1 also interacts with the Rab2 GAP protein TBC-8 and the BAR domain protein RIC-19, a RAB-2 effector. In summary, a pathway of conserved proteins controls the maturation of dense-core vesicles at the trans-Golgi network...