Gene Symbol: taf-4
Description: TAF (TBP-associated transcription factor) family
Alias: TAF (TBP-associated transcription factor) family
Species: Caenorhabditis elegans
Walker A, Rothman J, Shi Y, Blackwell T. Distinct requirements for C.elegans TAF(II)s in early embryonic transcription. EMBO J. 2001;20:5269-79 pubmed
..The broad involvement of TAF-5 in mRNA transcription in vivo suggests a requirement for either TFIID or a TFTC-like complex. ..
Walker A, Shi Y, Blackwell T. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. J Biol Chem. 2004;279:15339-47 pubmed
..Our findings imply that in metazoans TFIID may be of widespread importance for transcription and for expression of tissue-specific genes. ..
Guven Ozkan T, Nishi Y, Robertson S, Lin R. Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4. Cell. 2008;135:149-60 pubmed publisher
..We propose that phosphorylation by MBK-2 serves as a developmental switch, converting OMA-1/2 from oocyte to embryo regulators. ..
Walker A, Blackwell T. A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans. J Biol Chem. 2003;278:6181-6 pubmed
..Our findings suggest that TAF-5, TAF-9, and TAF-10 are part of a functional module of TFIID- and TFTC/SAGA-related complexes that can be bypassed in many metazoan-specific genes. ..
Lancero H, Castaneda S, Caberoy N, Ma X, Garza A, Shi W. Analysing protein-protein interactions of the Myxococcus xanthus Dif signalling pathway using the yeast two-hybrid system. Microbiology. 2005;151:1535-41 pubmed
..Based on these findings, a model for the Dif signalling pathway is proposed. ..
Khan M, Ligon M, Hussey L, Hufnal B, Farber R, Munkácsy E, et al
. TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Aging (Albany NY). 2013;5:741-58 pubmed
..Our findings suggest that the Mit phenotype is under the control of multiple transcriptional responses, and that TAF-4 and HIF-1 may be part of a general signaling axis that specifies Mit mutant life extension. ..
Spike C, Coetzee D, Nishi Y, Guven Ozkan T, Oldenbroek M, Yamamoto I, et al
. Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans. Genetics. 2014;198:1513-33 pubmed publisher
..Taken together, these data support a model in which the conserved regulators of mRNA translation LIN-41 and OMA-1/2 coordinately control oocyte growth and the proper spatial and temporal execution of the meiotic maturation decision. ..