Gene Symbol: taf-4
Description: TAF (TBP-associated transcription factor) family
Alias: TAF (TBP-associated transcription factor) family
Species: Caenorhabditis elegans

Top Publications

  1. Walker A, Rothman J, Shi Y, Blackwell T. Distinct requirements for C.elegans TAF(II)s in early embryonic transcription. EMBO J. 2001;20:5269-79 pubmed
    ..The broad involvement of TAF-5 in mRNA transcription in vivo suggests a requirement for either TFIID or a TFTC-like complex. ..
  2. Walker A, Shi Y, Blackwell T. An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription. J Biol Chem. 2004;279:15339-47 pubmed
    ..Our findings imply that in metazoans TFIID may be of widespread importance for transcription and for expression of tissue-specific genes. ..
  3. Guven Ozkan T, Nishi Y, Robertson S, Lin R. Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4. Cell. 2008;135:149-60 pubmed publisher
    ..We propose that phosphorylation by MBK-2 serves as a developmental switch, converting OMA-1/2 from oocyte to embryo regulators. ..
  4. Walker A, Blackwell T. A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans. J Biol Chem. 2003;278:6181-6 pubmed
    ..Our findings suggest that TAF-5, TAF-9, and TAF-10 are part of a functional module of TFIID- and TFTC/SAGA-related complexes that can be bypassed in many metazoan-specific genes. ..
  5. Lancero H, Castaneda S, Caberoy N, Ma X, Garza A, Shi W. Analysing protein-protein interactions of the Myxococcus xanthus Dif signalling pathway using the yeast two-hybrid system. Microbiology. 2005;151:1535-41 pubmed
    ..Based on these findings, a model for the Dif signalling pathway is proposed. ..
  6. Khan M, Ligon M, Hussey L, Hufnal B, Farber R, Munk√°csy E, et al. TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Aging (Albany NY). 2013;5:741-58 pubmed
    ..Our findings suggest that the Mit phenotype is under the control of multiple transcriptional responses, and that TAF-4 and HIF-1 may be part of a general signaling axis that specifies Mit mutant life extension. ..
  7. Spike C, Coetzee D, Nishi Y, Guven Ozkan T, Oldenbroek M, Yamamoto I, et al. Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans. Genetics. 2014;198:1513-33 pubmed publisher
    ..Taken together, these data support a model in which the conserved regulators of mRNA translation LIN-41 and OMA-1/2 coordinately control oocyte growth and the proper spatial and temporal execution of the meiotic maturation decision. ..