Gene Symbol: T07C4.3
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Alegado R, Tan M. Resistance to antimicrobial peptides contributes to persistence of Salmonella typhimurium in the C. elegans intestine. Cell Microbiol. 2008;10:1259-73 pubmed publisher
    ..elegans spp-1 was reduced by RNAi. Together, our data suggest that resistance to host antimicrobials in the intestinal lumen is a key mechanism for Salmonella persistence. ..
  2. Kawli T, Tan M. Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling. Nat Immunol. 2008;9:1415-24 pubmed publisher
    ..INS-7 secreted from the nervous system functioned in a non-cell autonomous way to activate the insulin pathway and alter basal and inducible expression of immunity-related genes in intestinal cells. ..
  3. Nandakumar M, Tan M. Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. PLoS Genet. 2008;4:e1000273 pubmed publisher
    ..The conservation of p38 MAP kinase signaling in both stress and immune responses further encourages exploring the function of GLA and SDA in humans. ..
  4. Evans E, Kawli T, Tan M. Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans. PLoS Pathog. 2008;4:e1000175 pubmed publisher
    ..Our results reveal a new mechanism by which P. aeruginosa suppresses host immune defense. ..